KHK
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Official Full Name
ketohexokinase (fructokinase)
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Overview
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
KHK; ketohexokinase (fructokinase); ketohexokinase; hepatic fructokinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- KHK Related Research Area
KHK involved in several pathways and played different roles in them. We selected most pathways KHK participated on our site, such as Fructose and mannose metabolism, Fructose catabolism, Fructose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with KHK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Fructose and mannose metabolism | HK1;AKR1B1;TIGARB;GMPPAB;TPI1B;AKR1B10;TIGARA;TPI1A;ALDOAB |
Fructose catabolism | |
Fructose metabolism | |
Metabolic pathways | AMY2B;URAD;AKR1B1;NADK2;AADAT;ACAD8;CYP2C70;ASPA;CKB |
Metabolism | PAOX;SPRB;UCP3;PDK3;MED31;COX6C;MED21;GRX2;ATP5S |
Metabolism of carbohydrates | SLC25A1A;B3GAT2;CHST14;SLC35D2;SLC25A12;STAB2;MAPK1IP1L;SLC25A13;HPSE |
Polyol pathway | |
sucrose degradation | KHK;GALM |
KHK has several biochemical functions, for example, ATP binding, ketohexokinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KHK itself. We selected most functions KHK had, and list some proteins which have the same functions with KHK. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | RFC5;STK32C;GLULA;BRIP1;SMARCA2;ABCB9;PHKG1;RARS2;PDPK1A |
ketohexokinase activity | |
protein binding | FLVCR1;NLRC4;CRABP2;TUBB2A;TNFSF10;SIPA1L2;OAZ3;WHSC1L1;LDLR |
KHK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KHK here. Most of them are supplied by our site. Hope this information will be useful for your research of KHK.
LHX9; 14786024; DEDD; CD2BP2; SNRPB; LCN1; ARRB1; LYZ; ILK; RNPS1; CDK5RAP3
- Q&As
- Reviews
Q&As (6)
Ask a questionActivity of KHK protein is affected by many factors, including gene expression, hormone levels, nutritional status, etc. In addition, some small molecule compounds can also regulate the activity of KHK proteins.
Some studies have shown that abnormal expression of the KHK protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the KHK protein may change. In addition, the KHK protein may also be a drug target for the treatment of these diseases.
The activity of the KHK protein can be modulated by drugs or other small molecule compounds to treat diseases related to the KHK protein. For example, some drugs can inhibit the activity of the KHK protein to treat diseases associated with abnormal metabolism of ketone bodies
Some studies have shown that mutations or abnormal expression of the KHK protein may be related to some diseases, such as cancer, neurodegenerative diseases, etc. However, the specific association needs to be confirmed by further research.
The interaction between the KHK protein and other enzymes or proteins is complex. For example, it may interact with fatty acid synthase to co-catalyze the synthesis of ketone bodies. In addition, it may interact with some regulators to regulate its activity.
The occurrence, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction of KHK protein with other proteins. These features can also be used to develop new biomarkers and drug targets.
Customer Reviews (3)
Write a reviewDue to the short half-life and high clearance characteristics of KHK, they can better adapt to the treatment needs of patients of different ages, providing patients with a safer and more effective treatment option.
The stability of KHK is so good that it can be manipulated experimentally for long periods of time without compromising its performance and results.
Reproducibility of the Western blot was significantly improved by using this protein.
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