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KHK

  • Official Full Name

    ketohexokinase (fructokinase)

  • Overview

    This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    KHK; ketohexokinase (fructokinase); ketohexokinase; hepatic fructokinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KHK-450H Active Recombinant Human KHK, His-tagged E.coli His
Human KHK-151H Recombinant Human KHK protein, T7-tagged E.coli T7
Human KHK-905H Recombinant Human Ketohexokinase (fructokinase) Human N/A
Human KHK-29896TH Recombinant Human KHK, T7 -tagged E.coli T7
Human KHK-493H Recombinant Human KHK protein, His-tagged HEK293 His Met1-Val298
Human KHK-492H Recombinant Human KHK, MYC/DDK-tagged HEK293 Myc/DDK
Human KHK-491H Recombinant Human Ketohexokinase E.coli His
Human KHK-29893TH Recombinant Human KHK E.coli N/A 298 amino acids
Human KHK-4985HCL Recombinant Human KHK 293 Cell Lysate HEK293 N/A
Human KHK-3134H Recombinant Human KHK protein, GST-tagged E.coli GST 1-298aa
Human KHK-1671H Recombinant Human KHK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KHK-3586HFL Recombinant Full Length Human KHK, Flag-tagged Mamanlian cells Flag
Human KHK-2378H Recombinant Human KHK Protein (Met1-Val298), C-His tagged Mammalian cells C-His Met1-Val298
Mouse KHK-8613M Recombinant Mouse KHK Protein Mammalian Cell His
Mouse KHK-4800M Recombinant Mouse KHK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Khk-1263M Recombinant Mouse Khk Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse KHK-4800M-B Recombinant Mouse KHK Protein Pre-coupled Magnetic Beads HEK293
Mouse Khk-3135M Recombinant Mouse Khk protein, His-tagged E.coli His 1-298aa
Rat KHK-3246R Recombinant Rat KHK Protein Mammalian Cell His
Rat KHK-2902R Recombinant Rat KHK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KHK-2902R-B Recombinant Rat KHK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KHK-747Z Recombinant Zebrafish KHK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KHK Related Research Area

KHK involved in several pathways and played different roles in them. We selected most pathways KHK participated on our site, such as Fructose and mannose metabolism, Fructose catabolism, Fructose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with KHK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fructose and mannose metabolismHK1;AKR1B1;TIGARB;GMPPAB;TPI1B;AKR1B10;TIGARA;TPI1A;ALDOAB
Fructose catabolism
Fructose metabolism
Metabolic pathwaysAMY2B;URAD;AKR1B1;NADK2;AADAT;ACAD8;CYP2C70;ASPA;CKB
MetabolismPAOX;SPRB;UCP3;PDK3;MED31;COX6C;MED21;GRX2;ATP5S
Metabolism of carbohydratesSLC25A1A;B3GAT2;CHST14;SLC35D2;SLC25A12;STAB2;MAPK1IP1L;SLC25A13;HPSE
Polyol pathway
sucrose degradationKHK;GALM

KHK has several biochemical functions, for example, ATP binding, ketohexokinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KHK itself. We selected most functions KHK had, and list some proteins which have the same functions with KHK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRFC5;STK32C;GLULA;BRIP1;SMARCA2;ABCB9;PHKG1;RARS2;PDPK1A
ketohexokinase activity
protein bindingFLVCR1;NLRC4;CRABP2;TUBB2A;TNFSF10;SIPA1L2;OAZ3;WHSC1L1;LDLR

KHK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KHK here. Most of them are supplied by our site. Hope this information will be useful for your research of KHK.

LHX9; 14786024; DEDD; CD2BP2; SNRPB; LCN1; ARRB1; LYZ; ILK; RNPS1; CDK5RAP3

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How is the activity of KHK protein regulated? 10/15/2022

Activity of KHK protein is affected by many factors, including gene expression, hormone levels, nutritional status, etc. In addition, some small molecule compounds can also regulate the activity of KHK proteins.

What is the relationship between KHK protein and the occurrence and progression of disease? 05/02/2022

Some studies have shown that abnormal expression of the KHK protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the KHK protein may change. In addition, the KHK protein may also be a drug target for the treatment of these diseases.

How to use the activity of KHK protein for disease treatment? 07/06/2021

The activity of the KHK protein can be modulated by drugs or other small molecule compounds to treat diseases related to the KHK protein. For example, some drugs can inhibit the activity of the KHK protein to treat diseases associated with abnormal metabolism of ketone bodies

What diseases are mutations or abnormal expression of the KHK protein associated with? 03/11/2021

Some studies have shown that mutations or abnormal expression of the KHK protein may be related to some diseases, such as cancer, neurodegenerative diseases, etc. However, the specific association needs to be confirmed by further research.

How about the interaction between the KHK protein and other enzymes or proteins? 02/14/2021

The interaction between the KHK protein and other enzymes or proteins is complex. For example, it may interact with fatty acid synthase to co-catalyze the synthesis of ketone bodies. In addition, it may interact with some regulators to regulate its activity.

How to use KHK protein for disease diagnosis? 12/15/2019

The occurrence, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction of KHK protein with other proteins. These features can also be used to develop new biomarkers and drug targets.

Customer Reviews (3)

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Reviews
12/03/2020

    Due to the short half-life and high clearance characteristics of KHK, they can better adapt to the treatment needs of patients of different ages, providing patients with a safer and more effective treatment option.

    12/30/2019

      The stability of KHK is so good that it can be manipulated experimentally for long periods of time without compromising its performance and results.

      09/19/2019

        Reproducibility of the Western blot was significantly improved by using this protein.

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