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KIF5A

Official Full Name

kinesin family member 5A
Overview

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
Synonyms

KIF5A; kinesin family member 5A; spastic paraplegia 10 (autosomal dominant) , SPG10; kinesin heavy chain isoform 5A; D12S1889; MY050; NKHC; KIF5A variant protein; neuronal kinesin heavy chain; kinesin heavy chain neuron-specific 1; kinesin, heavy chain, n;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|GST
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KIF5A-376H	Recombinant Human KIF5A, GST-tagged	E.coli	GST	C-102aa	$319 / 25ug
Human	KIF5A-259H	Recombinant Human KIF5A Protein, His-tagged	E.coli	His	Leu473~Cys605	$298 / 10ug
Human	KIF5A-2361H	Recombinant Human KIF5A Protein, His-tagged	E.coli	N-His	Val174-Lys315	Inquiry
Mouse	KIF5A-8647M	Recombinant Mouse KIF5A Protein	Mammalian Cell	His		Inquiry
Mouse	KIF5A-4819M	Recombinant Mouse KIF5A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Kif5a-260M	Recombinant Mouse Kif5a Protein, His/GST-tagged	E.coli	His/GST	Ala2~Ile211	$298 / 10ug
Mouse	KIF5A-4819M-B	Recombinant Mouse KIF5A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KIF5A-3258R	Recombinant Rat KIF5A Protein	Mammalian Cell	His		Inquiry
Rat	KIF5A-2914R	Recombinant Rat KIF5A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Kif5a-261R	Recombinant Rat Kif5a Protein, His/GST-tagged	E.coli	His/GST	Ile823~Ser1027	$298 / 10ug
Rat	KIF5A-2914R-B	Recombinant Rat KIF5A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
KIF5A Related Articles
KIF5A Related Gene Family

KIF5A involved in several pathways and played different roles in them. We selected most pathways KIF5A participated on our site, such as Adaptive Immune System, Dopaminergic synapse, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	SIGLEC7;CXADR;MALT1;CLTA;DCTN2;FGF20A;GRAP2A;AF251705;NA
Dopaminergic synapse	GNG2;CREB3L1;PPP2R2B;CREB5;GNB4;PPP2R5D;DRD4;PLCB4;CALM3
Endocytosis	EPN1;TGFB3;VTA1;NEDD4L;PARD6GB;PIP5K1BB;CYTH1A;CYTH1;CHMP4C
Factors involved in megakaryocyte development and platelet production	KIF5A;CABLES2;KIF15;ITPK1;KIF20A;ZFPM2A;KIF4;HBD;IRF1B
Hemostasis	SLC3A2A;GATA1;NFE2;DOCK7;LOC100514666;KIF2C;MAFGA;AKAP1B;JAM2B
Immune System	LRRFIP1;TRIM17;TRIM41;AP1B1;IFI30;RNF144B;MGC174857;CTSE;TXNIPB
Insulin processing	EXOC6;EXOC8;EXOC5;CPN1;SLC30A6;KIF5B;SLC30A8;EXOC3;RAB27A
Kinesins	KIF20A;KIF4;KIF3B;KIF18A;KIFAP3;KIF15;RACGAP1;CENPE;KIF2C

KIF5A has several biochemical functions, for example, ATP binding, ATP-dependent microtubule motor activity, plus-end-directed, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5A itself. We selected most functions KIF5A had, and list some proteins which have the same functions with KIF5A. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CHKB;CARNS1;ACSL4;DHX29;BMP2K;GLULB;KIF3CB;ACTC1;DDX11
ATP-dependent microtubule motor activity, plus-end-directed	KIF5AA;KIF18A;KIF5A;KIF1C;KIF11;KIF17;KIF16B;KIF19;KIF3A
microtubule binding	MAP1LC3B;SBDS;KIF17;BCL2L11;CLASP1;RACGAP1;TUBGCP5;JAKMIP3;MID2
motor activity	SMYHC2;DNAL4;MYH8;MYO1EB;MYH9A;CGNB;MYH9;MYH4;MYHC4
protein binding	SLC6A3;FAM54B;MDH1;LATS1;ARMCX1;TACR2;FSTL5;VPS53;C16orf87

KIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5A.

ANKRD27; RXRB; PCBD1; MDM2; Trak2; TRAK1; MAP4K4; TK1; Hap1; PIN1; TP53BP2; ITSN1; SMN1; TRAF3IP1; M

Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).

van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).