Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Kitlg

  • Official Full Name

    KIT ligand

  • Overview

    This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins.
  • Synonyms

    KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; Clo; Con; Gb; SLF; Sl; contrasted; cloud gray; grizzle-belly; hematopoietic growth factor KL; stem cell factor Location: 10 51.4 cM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Chicken
  • Dog
  • Equine
  • Feline
  • Felis catus (Cat) (Felis silvestris catus)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Swine
  • Barley Grain
  • CHO
  • Drosophila S2 Cell
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Hordeum Vulgare
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • P. pastoris
  • P.pastoris
  • Yeast
  • C
  • His
  • Fc
  • GST
  • hFc
  • Myc
  • His (Fc)
  • Avi
  • His|Avi
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KITLG-33H Active Recombinant Human KITLG, His-tagged Barley Grain His
Human KITLG-9128H Active Recombinant Human KITLG P.pastoris N/A
Human KITLG-20H Active Recombinant Human KITLG, HIgG1 Fc-tagged CHO Fc
Human KITLG-306H Active Recombinant Human KIT Ligand E.coli N/A
Human KITLG-522H Active Recombinant Human KITLG Protein, His-tagged, Biotinylated HEK293 His Glu 26 - Ala 190
Human KITLG-036E Active Recombinant Human KITLG (26-189aa), Met tagged E.coli N/A
Human KITLG-521H Active Recombinant Human KITLG, His tagged Human Cell N/A
Human KITLG-483H Active Recombinant Human KITLG, Fc-tagged CHO Fc
Human KITLG-22H Active Recombinant Human KITLG, MIgG2a Fc-tagged CHO Fc
Human KITLG-21H Active Recombinant Human KITLG, HIgG1 Fc-tagged, mutant CHO Fc
Human KITLG-961H Active Recombinant Human KITLG Protein E.coli N/A
Human KITLG-2105H Active Recombinant Human KITLG protein HEK293 N/A Glu 26 - His 214
Human KITLG-60H Recombinant Human KIT Ligand, His-tagged Insect Cell His
Human KITLG-19H Active Recombinant Human KITLG Protein, Pre-aliquoted E.coli Glu26-Ala189, with an N-terminal Met
Human KITLG-436H Recombinant Human KIT Ligand Drosophila S2 Cell N/A
Human KITLG-262H Recombinant Human KITLG, StrepII-tagged Human Cell Strep II 26-279, 254 a.a.
Human KITLG-558H Recombinant Human KITLG, His tagged Insect Cell His
Human KITLG-520H Recombinant Human KITLG protein HEK293 189
Human KITLG-1245H Recombinant Human KIT Ligand HEK293 N/A
Human KITLG-055H Recombinant Human KITLG Protein, His-tagged HEK293 His
Human KITLG-571HCL Recombinant Human KITLG cell lysate Insect Cell N/A
Human KITLG-4990H Recombinant Human KITLG protein, hFc-Myc-tagged HEK293 hFc-Myc 26-189aa
Human KITLG-129H Recombinant Human KITLG Protein, His-tagged Human Cell His Glu26-His214
Human SCF-116H Human Stem Cell Factor (rDNA derived) Reference standard N/A
Human KITLG-3136H Recombinant Human KITLG protein, GST-tagged E.coli GST 26-189aa
Human KITLG-2366H Recombinant Human KITLG Protein, His-tagged E.coli N-His Glu26-Ala217
Human KITLG-2056H Recombinant Human KITLG Protein, His-tagged HEK293 His Glu26-His214
Human KITLG-435HG Active GMP Recombinant Human KITLG protein HEK293 DNA sequence encoding Human SCF(NP_000890.1) was expressed with His tag at the C-terminal.
Human KITLG-325H Active Recombinant Human KITLG Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Glu 26 - Ala 190
Human KITLG-217H Active Recombinant Human KITLG Protein (Glu26-Ala189), C-His tagged, Animal-free, Carrier-free E.coli C-His Glu26-Ala189
Human KITLG-057K Active Recombinant Human KITLG Protein (165 aa) E.coli 165
Human KITLG-4339HG Active GMP Recombinant Human KITLG protein E.coli N/A
Human KITLG-199H Active Recombinant Human KITLG Protein E.coli
Human KITLG-5873H Recombinant Human KITLG Protein (Glu26-Ala189) E.coli Tag Free Glu26-Ala189
Human KITLG-15HG Active Recombinant Human KITLG Protein (Glu26-Ala189), GMP Grade, Animal-Free E.coli Glu26-Ala189
Human KITLG-525H Recombinant Human KITLG Protein 273
Human KITLG-141H Active Recombinant Human KITLG Protein E.coli Glu26-Ala189
Human KITLG-2584H Recombinant Human KITLG Protein (Glu26-His214), C-His tagged Mammalian cells C-His Glu26-His214
Human KITLG-2655H Active Recombinant Human KITLG protein, His-tagged HEK293 His Glu26-His214
Human KITLG-2585H Recombinant Human KITLG Protein (Glu26-Ala189), N-His tagged E.coli N-His Glu26-Ala189
Human KITLG-152K Active Recombinant Human KITLG Protein (165 aa) P. pastoris 165
Human KITLG-349H Active Recombinant Human KITLG protein, His-tagged HEK293 His Glu26-His214
Human KITLG-40HG Recombinant Human KITLG Protein, GMP Grade, Animal-Free E.coli
Human KITLG-726H Active Recombinant Human KITLG Protein E.coli Tag Free
Human KITLG-235H Recombinant Human KITLG Protein, Mature chain, Tag Free, Biotinylated HEK293 Tag Free Mature chain
Mouse Kitl-502M Active Recombinant Mouse Kitl, MIgG2a Fc-tagged CHO Fc
Mouse Kitl-501M Active Recombinant Mouse Interleukin Kitl, MIgG2a Fc-tagged, mutant CHO Fc
Mouse Kitl-307M Active Recombinant Mouse Kit Ligand E.coli N/A
Mouse Kitl-208M Active Recombinant Mouse Kitl P.pastoris N/A
Mouse Kitlg-34M Active Recombinant Mouse Kitlg, His-tagged Barley Grain His
Mouse Kitl-042E Active Recombinant Mouse Kitl (26-189aa) E.coli N/A
Mouse Kitlg-486M Recombinant Mouse Kitlg, Fc-tagged CHO Fc
Mouse Kitlg-5252M Recombinant Mouse Kit Ligand Mouse N/A
Mouse Kitl-792M Recombinant Mouse Kitl protein, His-tagged E.coli His Lys24~Ala247
Mouse Kitl-554M Recombinant Mouse Kitl protein E.coli N/A 165
Mouse Kitl-61M Recombinant Mouse Kit Ligand E.coli N/A
Mouse KITL-8666M Recombinant Mouse KITL Protein Mammalian Cell His
Mouse Kitl-1243M Recombinant Mouse Kit Ligand, His-tagged Hordeum Vulgare His
Mouse Kitl-577M Recombinant Mouse Kitl protein, His-tagged, Biotinylated. HEK293 His Lys 26 - Ala 189
Mouse KITLG-583MCL Recombinant Mouse KITLG cell lysate Insect Cell N/A
Mouse Kitl-3698M Active Recombinant Mouse Kitl Protein E. coli Lys26-Ala189
Mouse Kitl-552M Recombinant Mouse Kitl Protein E.coli N/A
Mouse Kitl-198M Active Recombinant Mouse Kitl Protein E.coli
Mouse Kitl-4378M Recombinant Mouse Kitl Protein Yeast N/A 165aa
Mouse Kitl-7281M Active Recombinant Mouse Kitl Protein E.coli 26-189
Mouse KITLG-829M Recombinant Mouse KITLG Protein (Met1-Ala189), His-tagged, Biotinylated Insect Cell His Met1-Ala189
Mouse Kitl-151K Active Recombinant Mouse Kitl Protein (165 aa) P. pastoris 165
Mouse KITL-154M Recombinant Mouse KITL Protein E.coli
Mouse Kitl-7284M Recombinant Mouse Kitl Protein E.coli 26-189
Mouse Kitlg-4827M Recombinant Mouse Kitlg Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Kitlg-4827M-B Recombinant Mouse Kitlg Protein Pre-coupled Magnetic Beads HEK293
Mouse Kitl-1713M Recombinant Mouse Kitl Protein, His-tagged E.coli N-His Lys24-Ala219
Mouse Kitl-3697M Active Recombinant Mouse Kitl Protein E. coli
Rat Kitlg-267R Active Recombinant Rat Kitlg, MIgG2a Fc-tagged CHO Fc
Rat Kitlg-63R Active Recombinant Rat Kitlg E.coli N/A
Rat Kitlg-584R Recombinant Rat Kitlg protein E.coli N/A 165
Rat Kitlg-62R Recombinant Rat Kit Ligand E.coli N/A
Rat Kitlg-793R Recombinant Rat Kitlg protein, His-tagged E.coli His Glu27~Glu259
Rat KITLG-3265R Recombinant Rat KITLG Protein Mammalian Cell His
Rat Kitlg-5267R Recombinant Rat KIT Ligand E.coli N/A
Rat Kitlg-150K Active Recombinant Rat Kitlg Protein (164 aa) P. pastoris 164
Rat KITLG-2921R Recombinant Rat KITLG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Kitlg-200R Recombinant Rat Kitlg Protein E.coli
Rat Kitlg-164K Active Recombinant Rat Kitlg Protein HEK293
Rat KITLG-2921R-B Recombinant Rat KITLG Protein Pre-coupled Magnetic Beads HEK293
Rabbit KITLG-4356R Recombinant Rabbit KITLG Protein Yeast N/A 188aa
Dog KITLG-2737D Recombinant Dog KITLG Protein, His-tagged HEK293F N-His Lys26-Val274
Bovine KITLG-4321B Recombinant Bovine KITLG Protein Yeast N/A 166aa
Canine KITLG-572D Recombinant Canine KITLG protein E.coli N/A 165
Canine KITLG-4388C Recombinant Canine KITLG Protein Yeast N/A 165aa
Equine KITLG-4392E Recombinant Equine KITLG Protein Yeast N/A 166aa
Feline KITLG-4379F Recombinant Feline KITLG Protein Yeast N/A 165aa
Felis catus (Cat) (Felis silvestris catus) RFL9710FF Recombinant Full Length Cat Kit Ligand(Kitlg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-274)
Homo sapiens (Human) RFL23935HF Recombinant Full Length Human Kit Ligand(Kitlg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-273)
Mus musculus (Mouse) RFL17953MF Recombinant Full Length Mouse Kit Ligand(Kitlg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-273)
Ovis aries (Sheep) RFL9869OF Recombinant Full Length Sheep Kit Ligand(Kitlg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-267)
Rattus norvegicus (Rat) RFL3095RF Recombinant Full Length Rat Kit Ligand(Kitlg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-273)
Swine KITLG-4355S Recombinant Swine KITLG Protein Yeast N/A 166aa
Pig KITLG-450P Recombinant Pig KITLG protein, His-tagged HEK293F His Thr25~Ala191
Chicken KITLG-38C Recombinant Chicken KITLG Protein E.coli N/A
Chicken KITLG-3748C Recombinant Chicken KITLG Mammalian Cell His
Chicken KITLG-39C Recombinant Chicken KITLG Protein Yeast
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Kitlg involved in several pathways and played different roles in them. We selected most pathways Kitlg participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kitlg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayCALML5;INS;KSR2;PLA2G2D;PDGFRB;ABL1;RASGRP3;PIK3R1;KLK1B4
Rap signaling pathwayFGF4;ITGB2;KLK1B4;FGF5;LPAR5;PDGFB;PIK3CA;MAP2K1;FGF14
Cytokine-cytokine receptor interactionCD70;IL22RA1;IFNAR2;IL10RB;VEGFB;CXCL5;PDGFAA;IL3RA;CXCR3.2
Phospholipase D signaling pathwayAKT1;GRM3;PDGFD;GRM1;PLCB1;MAPK3;PIK3CA;DNM3;GRM7
PIK-Akt signaling pathwayFN1;VEGFA;CREB3L2;TP53;IL2RA;PDGFA;IL6;MLST8;TRP53
Hematopoietic cell lineageCD37;IL7;GP1BB;CD59A;HLA-DRA;DNTT;IL7R;FCGR1;GM2002
MelanogenesisFZD7B;CALM3A;TCF7L2;MITFA;GNAI2;EP300;PLCB3;WNT2BB;WNT11B
Pathways in cancerSUFU;WNT10B;RXRA;PIK3CG;LPAR3;GNAI1;WNT9A;BMP4;LEF1

Kitlg has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kitlg itself. We selected most functions Kitlg had, and list some proteins which have the same functions with Kitlg. You can find most of the proteins on our site.

Function Related Protein
cytokine activityLEFTY1;IL4;NDR2;TNFB;IL1A;FGF2;WNT2;Gm13290;CSF3
growth factor activityCSF1;BDNF;NRTN;FGF8B;IL4;BMP2;FGF10;GDF1;GDF5
protein bindingHIST1H2AG;TULP3;C19orf10;GTF2F1;INPP5D;PARD6A;RAD21;NPBWR1;TMEM218
stem cell factor receptor bindingKITLGA;KITLGB;SPRED2;SPRED1;KITLG;Kitl

Kitlg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kitlg here. Most of them are supplied by our site. Hope this information will be useful for your research of Kitlg.

KIT; FLT3LG

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does KITLG influence stem cell factor (SCF) signaling pathways? 11/10/2022

Overexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.

What are the implications of KITLG in oncogenesis and tumor progression? 07/20/2022

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

What role does KITLG play in melanogenesis and pigmentation? 01/17/2022

Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.

Are there any known disorders associated with mutations or dysregulation of KITLG? 06/22/2020

Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.

What is the primary biological function of KITLG in the hematopoietic system? 04/12/2020

KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.

How has KITLG been explored as a therapeutic target or agent in clinical settings? 02/10/2020

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

How does KITLG interact with its receptor, c-KIT? 12/21/2019

KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.

Customer Reviews (3)

Write a review
Reviews
01/23/2022

    Reliable for immunoprecipitation assay.

    03/01/2021

      No contamination, very clean.

      02/09/2020

        Worked perfectly in Western.

        Ask a Question for All Kitlg Products

        Required fields are marked with *

        My Review for All Kitlg Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends