Kitlg
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Official Full Name
KIT ligand
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Overview
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins. -
Synonyms
KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; Clo; Con; Gb; SLF; Sl; contrasted; cloud gray; grizzle-belly; hematopoietic growth factor KL; stem cell factor Location: 10 51.4 cM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Chicken
- Dog
- Equine
- Feline
- Felis catus (Cat) (Felis silvestris catus)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pig
- Rabbit
- Rat
- Rattus norvegicus (Rat)
- Swine
- Barley Grain
- CHO
- Drosophila S2 Cell
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- Hordeum Vulgare
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- P. pastoris
- P.pastoris
- Yeast
- C
- His
- Fc
- GST
- hFc
- Myc
- His (Fc)
- Avi
- His|Avi
- N/A
- N
- Strep II
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
Kitlg involved in several pathways and played different roles in them. We selected most pathways Kitlg participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kitlg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | CALML5;INS;KSR2;PLA2G2D;PDGFRB;ABL1;RASGRP3;PIK3R1;KLK1B4 |
Rap signaling pathway | FGF4;ITGB2;KLK1B4;FGF5;LPAR5;PDGFB;PIK3CA;MAP2K1;FGF14 |
Cytokine-cytokine receptor interaction | CD70;IL22RA1;IFNAR2;IL10RB;VEGFB;CXCL5;PDGFAA;IL3RA;CXCR3.2 |
Phospholipase D signaling pathway | AKT1;GRM3;PDGFD;GRM1;PLCB1;MAPK3;PIK3CA;DNM3;GRM7 |
PIK-Akt signaling pathway | FN1;VEGFA;CREB3L2;TP53;IL2RA;PDGFA;IL6;MLST8;TRP53 |
Hematopoietic cell lineage | CD37;IL7;GP1BB;CD59A;HLA-DRA;DNTT;IL7R;FCGR1;GM2002 |
Melanogenesis | FZD7B;CALM3A;TCF7L2;MITFA;GNAI2;EP300;PLCB3;WNT2BB;WNT11B |
Pathways in cancer | SUFU;WNT10B;RXRA;PIK3CG;LPAR3;GNAI1;WNT9A;BMP4;LEF1 |
Kitlg has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kitlg itself. We selected most functions Kitlg had, and list some proteins which have the same functions with Kitlg. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | LEFTY1;IL4;NDR2;TNFB;IL1A;FGF2;WNT2;Gm13290;CSF3 |
growth factor activity | CSF1;BDNF;NRTN;FGF8B;IL4;BMP2;FGF10;GDF1;GDF5 |
protein binding | HIST1H2AG;TULP3;C19orf10;GTF2F1;INPP5D;PARD6A;RAD21;NPBWR1;TMEM218 |
stem cell factor receptor binding | KITLGA;KITLGB;SPRED2;SPRED1;KITLG;Kitl |
Kitlg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kitlg here. Most of them are supplied by our site. Hope this information will be useful for your research of Kitlg.
KIT; FLT3LG
- Q&As
- Reviews
Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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