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KLC3

  • Official Full Name

    kinesin light chain 3

  • Overview

    This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.
  • Synonyms

    KLC3; kinesin light chain 3; KLC2L; KLCt; KNS2B; Kinesin light chain 2; KLC2; KLC2 like; KLC2-like; KLC3_HUMAN;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLC3-937HCL Recombinant Human KLC3 cell lysate N/A
Human KLC3-1975H Recombinant Human KLC3 Protein (1-504 aa), His-SUMO-tagged E.coli His/SUMO 1-504 aa
Human KLC3-1979H Recombinant Human KLC3 Protein (1-504 aa), His-tagged Yeast His 1-504 aa
Human KLC3-3281H Recombinant Human KLC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KLC3-301134H Recombinant Human KLC3 protein, GST-tagged E.coli GST Met1-Pro196
Human KLC3-2367H Recombinant Human KLC3 Protein, His-tagged E.coli N-His Met1-Arg306
Mouse KLC3-8671M Recombinant Mouse KLC3 Protein Mammalian Cell His
Mouse KLC3-4831M Recombinant Mouse KLC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Klc3-3699M Recombinant Mouse Klc3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse KLC3-4831M-B Recombinant Mouse KLC3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Klc3-1716M Recombinant Mouse Klc3 Protein, His-tagged E.coli N-His Met1-Val258
Rat KLC3-3268R Recombinant Rat KLC3 Protein Mammalian Cell His
Rat KLC3-2924R-B Recombinant Rat KLC3 Protein Pre-coupled Magnetic Beads HEK293
Rat KLC3-2924R Recombinant Rat KLC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish KLC3-4631Z Recombinant Zebrafish KLC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KLC3 Related Articles

KLC3 involved in several pathways and played different roles in them. We selected most pathways KLC3 participated on our site, such as Adaptive Immune System, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemASB13;CD300LH;AGO1;LRSAM1;ARIH2;BLMH;CTSL2;RASGRP1;NA
Factors involved in megakaryocyte development and platelet productionDOCK8;GATA1;ZFPM1;KIFAP3;DOCK11;DOCK9;MGC173646;MAFF;DOCK7
HemostasisCFHL4;D-AKAP2;MFN1;CLU;MMRN1;F3A;KIF22;ITPK1;AASS
Immune SystemUBE2F;SIGIRR;ASB8;KIF2B;DYNC1I2;IFIT12;RNF144B;FBXO44;KIF26A
KinesinsKIF4;KIF4A;KIF3C;KIF22;KIF5A;KIF11;RACGAP1;CENPE;KLC3
MHC class II antigen presentationMGC174152;AP1S3A;RACGAP1;KLC3;CTSLL;KIFAP3;CTSE;DCTN6;KIF22
RHO GTPase EffectorsKTN1;ERCC6L;PRC1B;ABI1B;ABI1A;WIPF2;MIS12;WASF3;NSL1
RHO GTPases activate KTN1KLC3;KTN1

KLC3 has several biochemical functions, for example, kinesin binding, microtubule binding, microtubule motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLC3 itself. We selected most functions KLC3 had, and list some proteins which have the same functions with KLC3. You can find most of the proteins on our site.

Function Related Protein
kinesin bindingFAM83D;KIF1B;MAPK8IP3;NEK6;KIAA1279;JIP1;TOR1A;KIF18B;KTN1
microtubule bindingKIF13B;KIF15;GAS2L1;PAFAH1B1;CAMSAP1A;RCC2;MID1;CDK5RAP2;CAMSAP1B
microtubule motor activityKIF11;KIF14;DNALI1;KIF9;KIF15;KIF21A;DYNC1LI2;KLC4;KIF2B
protein bindingKDM5B;PAIP1;CD80;BANK1;MICALL1;ARID3B;IP6K2;EIF1AX;EXD1

KLC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLC3.

KRT13; CCDC64B; 147700; NECAB2; NDC80; STX11; TCF4

Bhullar, B; Zhang, Y; et al. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. JOURNAL OF BIOLOGICAL CHEMISTRY 278:16159-16168(2003).
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