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KLF12

Official Full Name

Kruppel-like factor 12
Overview

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

KLF12; Kruppel-like factor 12; Krueppel-like factor 12; AP 2 repressor; AP 2rep; AP 2rep transcription factor; AP2REP; HSPC122; KLF12 zinc finger transcriptional repressor; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik; OTTHUMP00000018503; 2700063E05Rik; AI225908; AP-2 repressor; AP-2rep transcription factor; Krueppel like factor 12; Transcriptional repressor AP 2rep; transcriptional repressor AP-2rep;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KLF12-602H	Recombinant Human Kruppel-like factor 12, His-tagged	E.coli	His	Inquiry
Mouse	KLF12-8676M	Recombinant Mouse KLF12 Protein	Mammalian Cell	His	Inquiry
Mouse	KLF12-4835M	Recombinant Mouse KLF12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	KLF12-4835M-B	Recombinant Mouse KLF12 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	KLF12-2413R	Recombinant Rhesus monkey KLF12 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	KLF12-2234R	Recombinant Rhesus Macaque KLF12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	KLF12-2234R-B	Recombinant Rhesus Macaque KLF12 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KLF12 Related Articles

KLF12 involved in several pathways and played different roles in them. We selected most pathways KLF12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

KLF12 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF12 itself. We selected most functions KLF12 had, and list some proteins which have the same functions with KLF12. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POLR2E;ZHX1;ZNF684;ZBTB24;ZNF69;ZNF652;ZFPM2;ZFP92;KAT6A
RNA polymerase II regulatory region sequence-specific DNA binding	RUNX3;ZMYND11;ZNF8;ZNF480;CSDA;CDX1A;ZSCAN20;RXRG;RELB
metal ion binding	ASAP2B;MTBL;ZFP553;XRCC6BP1;FBXO40.1;Adamts19;ZNF143B;ZBTB25;MYLK
protein binding	VIL1;PMP22;GABPB1;NUP62CL;TUBA3E;NEUROG3;TP53BP1;UBE2D2;VHL
transcription corepressor activity	AES;KLF12;PIAS1;PSMC3;ZHX3;CDYL;RYBP;ZFPM1;TBL1Y
transcription factor activity, sequence-specific DNA binding	HES6;TEAD4;FLI1A;ZIM3;Ar;CTNNB1;PHTF1;ESR1;ELF3
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	POU5F1;PCGF6;MSX1;HES6;CGGBP1;FOXO3;HIST2H3A;ZEB1;HOXD9

KLF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF12.

CTBP1; THAP1; EHMT2

Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).