KLHL12
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Official Full Name
kelch-like 12 (Drosophila)
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Overview
Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene. KLHL12 has been shown to interact with RIT1 and CUL3. -
Synonyms
KLHL12; kelch-like 12 (Drosophila); kelch-like protein 12; C3IP1; CUL3 interacting protein 1; CUL3-interacting protein 1; DKIR; FLJ27152; Kelch like 12 (Drosophila); Kelch like 12; Kelch like 12 variant; Kelch like protein 12; Kelch like protein C3IP1; KLH12_HUMAN; KLHL 12; OTTHUMP00000038799; kelch-like protein C3IP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- GST|His
- His
- His (Fc)
- Avi
- Myc
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
KLHL12 involved in several pathways and played different roles in them. We selected most pathways KLHL12 participated on our site, such as Canonical Wnt signaling pathway, Degradation of DVL, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Canonical Wnt signaling pathway | CSNK1E;DVL1;CSNK1A1;KLHL12;DVL2;CSNK1D;DVL3 |
| Degradation of DVL | KLHL12;DVL2;HECW1B;DACT1;DVL1;HECW1;DVL3 |
| Signal Transduction | CDC73;C;CXCR7B;CRABP1B;RGS21;NOXA1;PDE10A;PRICKLE1B;ANXA1B |
| Signaling by Wnt | TMED5;ASH2L;PRICKLE1;SOX32;CDC73;RSPO3;LGR4;RNF146;SOX7 |
| TCF dependent signaling in response to WNT | RYK;HECW1B;DACT1;SOX13;SOX7;USP34;LGR5;RSPO2;SOX4B |
KLHL12 has several biochemical functions, for example, protein binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHL12 itself. We selected most functions KLHL12 had, and list some proteins which have the same functions with KLHL12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IFIT2;GTF2A1L;CYSLTR2;MSI2;DIXDC1;CCDC42;KRTAP9-4;DDX20;CHMP4C |
| contributes_to ubiquitin-protein transferase activity | BTRC;KLHL33;CCIN;TCEB3C;UBE2S;KLHL3;KBTBD12;RBX1;KLHDC7A |
KLHL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHL12.
PEF1; BAG6; SNX20; PRR13; ZBP1
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