KLK8
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Official Full Name
kallikrein-related peptidase 8
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Overview
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] -
Synonyms
KLK8; kallikrein-related peptidase 8; NP; HNP; NRPN; PRSS19; TADG14; kallikrein-8; ovasin; serine protease 19; serine protease TADG-14; tumor-associated differentially expressed gene 14 protein; BSP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- DDK
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- KLK8 Related Research Area
KLK8 involved in several pathways and played different roles in them. We selected most pathways KLK8 participated on our site, such as Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spinal Cord Injury | OMG;MBP;GAP43;LILRB3;AIF1;TNFSF13B;NOX4;LGALS3;RTN4 |
KLK8 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK8 itself. We selected most functions KLK8 had, and list some proteins which have the same functions with KLK8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FGF21;PPM1A;FERD3L;GOLSYN;PAQR5;PRPF3;GNG5;TSSK6;FCGR1A |
| serine-type endopeptidase activity | KLK4;Gzmd;TMPRSS4B;PCSK7;ST14A;PRSS1;C1RL;IMMP1L;PRSS42 |
KLK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK8.
NOTCH2NL; ZDHHC17; RGS2
- Q&As
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