Background
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane;and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin;B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative;splicing occurs at this locus and two transcript variants encoding the same protein have been identified.