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LCOR

  • Official Full Name

    ligand dependent nuclear receptor corepressor

  • Overview

    LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound;nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al.,;2003 (PubMed 12535528)).
  • Synonyms

    LCOR; ligand dependent nuclear receptor corepressor; ligand-dependent corepressor; FLJ38026; KIAA1795; MLR2; A630025C20RIK; LCOR_HUMAN; Ligand dependent corepressor; Mblk1 related protein 2; Mblk1-related protein 2; RP11 175O19.1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LCOR-527H Recombinant Human LCOR, GST-tagged E.coli GST 1-406aa
Human LCOR-976HCL Recombinant Human LCOR cell lysate N/A
Human LCOR-5396H Recombinant Human LCOR Protein, GST-tagged Wheat Germ GST
Zebrafish LCOR-4929Z Recombinant Zebrafish LCOR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LCOR Related Articles

LCOR involved in several pathways and played different roles in them. We selected most pathways LCOR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LCOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

LCOR has several biochemical functions, for example, DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LCOR itself. We selected most functions LCOR had, and list some proteins which have the same functions with LCOR. You can find most of the proteins on our site.

Function Related Protein
DNA bindingFBXL19;LZTS1;PAX8;HIST2H2BE;OTPB;POU1F1;PLAGL1;HOXB8B;RUNX1T1
protein bindingC1QTNF3;C16orf53;ZNF572;RMI1;COL6A5;IL32;ADAP1;DUSP21;CCAR1
transcription factor activity, sequence-specific DNA bindingTBX2B;NR5A1A;HOXC5A;IRF3;HOXB8A;TEAD1A;TBX5;CSRNP1;FUBP1
transcription factor bindingHHEX;CXXC5;CDK9;HDAC8;SLC26A5;PBX2;DDX3X;EGR1;TFDP1A

LCOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCOR here. Most of them are supplied by our site. Hope this information will be useful for your research of LCOR.

CTBP2; GOLGA2; TRAF1; CTBP2

Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).
Chien, PY; Ito, M; et al. A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. MOLECULAR ENDOCRINOLOGY 13:2122-2136(1999).
Boutell, JM; Thomas, P; et al. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. HUMAN MOLECULAR GENETICS 8:1647-1655(1999).
  • Q&As
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