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Lhcgr

  • Official Full Name

    luteinizing hormone/choriogonadotropin receptor

  • Overview

    This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
  • Synonyms

    LHCGR; luteinizing hormone/choriogonadotropin receptor; HHG, hypergonadotropic hypogonadism; lutropin-choriogonadotropic hormone receptor; LCGR; LGR2; LHR; ULG5; hypergonadotropic hypogonadism; lutropin/choriogonadotropin receptor; HHG; LHRHR; LSH-R; LH/CGR; LH/CG-R; FLJ41504; LH/Hcg Receptor, Extracellular Domain;

  • Recombinant Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rat
  • Sus scrofa (Pig)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LHCGR-1442H Recombinant Human LHCGR Protein (27-363 aa), His-tagged Yeast His 27-363 aa
Human LHCGR-023H Recombinant Human LHCGR protein, His-tagged E. coli His 49-219 aa
Human LHCGR-623H Recombinant Human LHCGR Protein (27-363 aa), His-tagged E.coli His 27-363 aa
Human LHCGR-64H Human Luteinizing Hormone Reference standard N/A
Human LHCGR-5031H Recombinant Human LHCGR protein, His-tagged HEK293 His 27-363aa
Human LHCGR-1046HFL Recombinant Human LHCGR protein, His&Flag-tagged HEK293 His&Flag 1-699 aa
Mouse LHCGR-9079M Recombinant Mouse LHCGR Protein Mammalian Cell His
Mouse LHCGR-5067M Recombinant Mouse LHCGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LHCGR-5067M-B Recombinant Mouse LHCGR Protein Pre-coupled Magnetic Beads HEK293
Rat LHCGR-3398R Recombinant Rat LHCGR Protein Mammalian Cell His
Rat LHCGR-1443R Recombinant Rat LHCGR Protein (27-362 aa), His-tagged Yeast His 27-362 aa
Rat LHCGR-3054R-B Recombinant Rat LHCGR Protein Pre-coupled Magnetic Beads HEK293
Rat LHCGR-3054R Recombinant Rat LHCGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Lhcgr-5032R Recombinant Rat Lhcgr protein, Flag-tagged HEK293 Flag 27-362aa
Rat LHCGR-624R Recombinant Rat LHCGR Protein (27-362 aa), His-SUMO-tagged E.coli His/SUMO 27-362 aa
Bos taurus (Bovine) RFL33560BF Recombinant Full Length Bovine Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-701)
Callithrix jacchus (White-tufted-ear marmoset) RFL17243CF Recombinant Full Length Callithrix Jacchus Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-676)
Gallus gallus (Chicken) RFL11373GF Recombinant Full Length Chicken Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Mus musculus (Mouse) RFL11946MF Recombinant Full Length Mouse Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-700)
Ovis aries (Sheep) RFL15809OF Recombinant Full Length Sheep Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length (1-538)
Sus scrofa (Pig) RFL34055SF Recombinant Full Length Pig Lutropin-Choriogonadotropic Hormone Receptor(Lhcgr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-696)
Zebrafish LHCGR-11660Z Recombinant Zebrafish LHCGR Mammalian Cell His
Chicken LHCGR-6496C Recombinant Chicken LHCGR Mammalian Cell His
Kit-1077 HRV 3C Protease Activity Assay Kit (Colorimetric) N/A
Kit-1025 Total Sulfite Assay Kit (Colorimetric) N/A
Kit-1364 LHCGR CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1365 cAMP LHCGR CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Lhcgr Related Articles

Lhcgr involved in several pathways and played different roles in them. We selected most pathways Lhcgr participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lhcgr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPTAFR;CCKAR;SLC8A2B;HTR5AL;P2RX3A;P2RX3B;PLCB3;GRIN2C;TACR1
Neuroactive ligand-receptor interactionCHRNA1;MAS1;PPYR1;NPY4R;PRLHR;F2RL1.1;TACR3A;OXTR;GRPR
Ovarian steroidogenesisACOT2;ALOX5;STAR;HSD3B2;AKR1C3;HSD3B5;INS;PRKACB;PLA2G4F
Prolactin signaling pathwaySIRPA;PIK3CB;SOS1;MAPK11;INS;STAT5A;SHC1;MAPK3;STAT1

Lhcgr has several biochemical functions, for example, G-protein coupled peptide receptor activity, choriogonadotropin hormone binding, choriogonadotropin hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lhcgr itself. We selected most functions Lhcgr had, and list some proteins which have the same functions with Lhcgr. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled peptide receptor activityFSHR;RXFP4;RXFP3;GRPR;GPR84;MC1R;LTB4R2;LHCGR;LTB4R
choriogonadotropin hormone binding
choriogonadotropin hormone receptor activity
luteinizing hormone receptor activity

Lhcgr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lhcgr here. Most of them are supplied by our site. Hope this information will be useful for your research of Lhcgr.

Liaqat, I; Jahan, N; et al. Genetic Polymorphisms in Pakistani Women With Polycystic Ovary Syndrome. REPRODUCTIVE SCIENCES 22:347-357(2015).
McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).
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