LOX
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Official Full Name
lysyl oxidase
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Overview
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LOX; lysyl oxidase; protein-lysine 6-oxidase; ras excision protein; ras recision gene (rrg); TSC-160; AI893619;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Assay Kits
- Aerococcuss viridans
- Chicken
- Human
- Mouse
- Pseudomonas aeruginosa
- Rat
- Zebrafish
- Aerococcuss viridans
- E.coli
- HEK293
- HEK293F
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- DDK|His
- Flag
- His
- GST
- His (Fc)
- Avi
- His|GST
- SUMO
- Myc
- MBP
- DDK
- MYC
- N/A
- N
- TwinStrep
- T7|His
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- LOX Related Articles
- LOX Related Research Area
LOX involved in several pathways and played different roles in them. We selected most pathways LOX participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of collagen fibrils and other multimeric structures | COL4A6;CTSL1;CTSL2;MMP13;COL8A2;COL10A1A;COL5A3A;CD151;PCOLCE |
| Collagen formation | COL16A1;COL28A1D;COL10A1;BMP1;COL13A1;COL9A1B;PCOLCE;SERPINH1B;COL4A6 |
| Crosslinking of collagen fibrils | LOX;ABHD1;LOXL4;BMP1B;BMP1;LOXL2;BMP1A;TLL1;LOXL3 |
| Elastic fibre formation | FBLN1;MFAP5;ABHD1;MFAP4;LTBP2;FBLN2;MFAP3;MFAP2;LOXL2 |
| Extracellular matrix organization | DMP1;MUSK;COL19A1;COL8A1A;DDR1;TLL2;COL17A1A;COL17A1;LEPRE1 |
LOX has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOX itself. We selected most functions LOX had, and list some proteins which have the same functions with LOX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | LOXL3B;CUTC;SLC11A2;IL1A;PRNPA;LOXL5A;COX17;AOC1;PAM |
| protein binding | PVRL4;CCR1;OLIG3;PHLPP1;SCLY;CSF1;FTCD;NDFIP2;ABCF1 |
| protein-lysine 6-oxidase activity | POLR1B;LOX;LOXL2;LOXL3;LOXL4;ABHD1;LOXL2B;LOXL2A |
LOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOX here. Most of them are supplied by our site. Hope this information will be useful for your research of LOX.
EFEMP2; PTPRK; FBLN5; ELN; FBN1; GATAD2B; HSPA1A; COL1A1; COL3A1
- Q&As
- Reviews
Q&As (4)
Ask a questionLOX interacts with H1 histones.
LOX overexpression leads to increased cell death and abnormal mitosis.
LOX-catalyzed extracellular matrix deamidation of lysine and hydroxylysine initiates covalent intermolecular cross-linking of elastin and collagen to form a meshwork that enhances the stability and integrity of extracellular matrix proteins.
LOX is mainly localized in the nucleus.
Customer Reviews (3)
Write a reviewThe technician modified my experimental protocol so that my experiment went smoothly.
Cheap price, high quality products, worth buying again！
The LOX proteins purchased from your company is suitable for WB.
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