LTBR
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Official Full Name
lymphotoxin beta receptor (TNFR superfamily, member 3)
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Overview
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. -
Synonyms
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; CD 18; CD18; CD18 antigen; LT beta R; LTBETAR; Lymphotoxin B receptor; Lymphotoxin beta receptor; TNFR superfamily member 3; TNFR2RP; TNFRII; TNFRRP; TNFRSF 3; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2 related protein; Tumor necrosis factor receptor superfamily member 3 precursor; TNF-RIII; TNFR-III; OTTHUMP00000238625; OTTHUMP00000238626; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor receptor type II; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III;
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Cynomolgus
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293 Cells
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse
- Wheat Germ
- C
- Fc
- hFc
- Fc Chimera
- His(C
- ter)
- GST
- His
- His (Fc)
- Avi
- His|GST
- human|IgG1|Fc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LTBR Related Gene Family
- LTBR Related Research Area
- LTBR Related Signal Pathway
LTBR involved in several pathways and played different roles in them. We selected most pathways LTBR participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTBR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CCL21;GM-CSF;CCL24;TNFSF12;IL12RB1;RELT;Ifna11;CXCR3.2;CSF2RA |
NF-kappa B signaling pathway | Bcl2a1b;LTBR;BCL2L1;CCL13;TRIM25;CD40LG;RELB;BIRC2;BCL10 |
HIF- signaling pathway | PDK1;MAPK3;PLCG2;VEGFA;ERBB2;TIMP1;IGF1;TFRC;PFKFB3 |
Intestinal i | CCR10;MHC2DCB;BMA2;CCL25B;CXCL12A;MHC2A;H2-AB1;TNFRSF17;CXCL12 |
ne network for IgA production | IL6;MAP3K14;HLA-DQA1;CXCL12A;HLA-DOA;HLA-DRB1;IL5;CCL28;CCL25 |
HTLV-I infection | FZD9;HLA-DOA;TRP53INP1;WNT2B;MAPK8;RRAS;TSPO;IL2RG;ETS2 |
Viral carcinogenesis | HPN;CDC42;ACTN1;NFKBIA;TBPL1;HNRNPK;GTF2H3;IL6ST;HIST1H2BF |
LTBR has several biochemical functions, for example, identical protein binding, protein binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LTBR itself. We selected most functions LTBR had, and list some proteins which have the same functions with LTBR. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
identical protein binding | PPP5C;ZNF703;TRIP13;PTS;AGER;DIAPH1;SNX16;GNPNAT1;DPP4 |
protein binding | PPP1R9B;LATS1;GSE1;MMP9;TRAF5;TRIP10;INTS9;ALDOC;TREML1 |
tumor necrosis factor-activated receptor activity | TNFRSF1A;TNFRSFA;CD40;TNFRSF10B;EDA2R;TNFRSF9A;TNFRSF8;TNFRSF11B;TNFRSF25 |
ubiquitin protein ligase binding | ERBB2;UBE2KB;SCN5A;CDC34A;Fzd4;TOLLIP;MFN2;PPARGC1A;TRIB2 |
LTBR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTBR here. Most of them are supplied by our site. Hope this information will be useful for your research of LTBR.
p29846-pro_0000037666; ZMYND11; DEAF1; TRAF2; TRAF3; BALF4 (provisional); HES1; q00653-pro_000003032; Bmpr1a; NFKB2
- Q&As
- Reviews
Q&As (7)
Ask a questionTherapeutic strategies targeting LTBR include inhibition of its signaling pathways, modulation of immune response, and anti-cancer approaches. Inhibitors of the NF-κB pathway, such as small molecule inhibitors or neutralizing antibodies, can be used to block LTBR-mediated signaling and reduce inflammation or tumor growth.
Current research on LTBR aims to further elucidate its role in disease mechanisms, particularly in autoimmune disorders, chronic inflammation, and cancer. Studies are investigating the downstream effects of LTBR activation, its involvement in immune cell function, and the identification of potential therapeutic targets within the LTBR signaling pathway.
The expression of LTBR is regulated by transcription factors and signaling pathways. For example, NF-κB and AP-1 transcription factors can bind to the promoter region of LTBR gene and enhance its expression. Additionally, cytokines and growth factors can also influence LTBR expression through downstream signaling cascades.
The LTBR signaling pathway interacts with various other signaling pathways, including those activated by TNFR1, TNFR2, and CD40. These interactions can lead to crosstalk and amplification of signaling, resulting in enhanced cellular responses. Understanding these interactions is crucial for elucidating the complex network of signaling events involved in disease pathogenesis.
LTBR, a membrane protein belonging to the tumor necrosis factor receptor superfamily, regulates various cellular processes such as inflammation, immune response, and lymphoid organ development. It activates signaling pathways including the NF-κB pathway and non-canonical NF-κB pathway.
Yes, certain genetic variants have been identified that are associated with altered LTBR expression and disease susceptibility. These variants can affect the binding of transcription factors or alter the stability of LTBR mRNA, leading to dysregulation of LTBR expression and increased risk of certain diseases.
Future research directions in LTBR include exploring the molecular mechanisms underlying LTBR-mediated signaling, investigating the impact of LTBR genetic variants on disease susceptibility, and developing novel therapeutic strategies targeting LTBR. Additionally, studying the interplay between LTBR and other signaling pathways may uncover new insights into disease pathogenesis and identify new therapeutic avenues.
Customer Reviews (3)
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