LTC4S
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Official Full Name
leukotriene C4 synthase
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Overview
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. -
Synonyms
LTC4S; leukotriene C4 synthase; MGC33147; Leukotriene C(4) synthase; LTC4 synthase; OTTHUMP00000197039;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cavia porcellus (Guinea pig)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LTC4S Related Articles
LTC4S involved in several pathways and played different roles in them. We selected most pathways LTC4S participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTC4S were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PTGES2;CYP4F11;GPX8;PLA2G10;PLA2G2D;CYP4F2;FAAH2A;CYP2C50;CYP1B1 |
| Metabolic pathways | AGXT;LDHA;COQ7;NAT8L;POLA2;DGKAA;P4HA1A;GPI;AMY2A4 |
LTC4S has several biochemical functions, for example, enzyme activator activity, glutathione binding, glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LTC4S itself. We selected most functions LTC4S had, and list some proteins which have the same functions with LTC4S. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | MMP15;PITRM1;DBF4;CLPSL1;CTSA;DAOA;TIMP2;APOA5;MMP17 |
| glutathione binding | GSTM3;GSTM4;GSTP2;PTGES2;PTGESL;GSTM1;LANCL1;LTC4S;GSS |
| glutathione peroxidase activity | MGST1;GPX1A;MGST2;GPX5;LTC4S;GSTT1;GPX1B;GPX4B;PRDX6 |
| glutathione transferase activity | EEF1G;GSTM5;GSTT4;MGST3;HPGDS;GDAP1L1;GSTT1;GSTA1;GSTM4 |
| leukotriene-C4 synthase activity | MGST2;LTC4S |
| lipid binding | DLC1;PAQR7B;AP2M1A;APOA4A;STARD7;BPIFB2;APOA5;SH3GL1;FAM123C |
| protein binding | TTC35;EAF1;CHIC2;ZNRF1;SPI1B;RPL28;TOMM20;UNC119B;CHMP4B |
| protein heterodimerization activity | ADIPOR2;SOX4;PANX1;SCGB2A1;ROPN1B;BTBD11A;MICU1;CAPN2;PDZD7 |
LTC4S has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTC4S here. Most of them are supplied by our site. Hope this information will be useful for your research of LTC4S.
- Q&As
- Reviews
Q&As (5)
Ask a questionLTC4S protein catalyzes the conversion of arachidonic acid to leukotriene C4, which contributes to the inflammatory response in conditions such as asthma and allergic reactions.
Studies have shown that increased expression of LTC4S protein is associated with more severe asthma symptoms and poor response to standard asthma medications.
Genetic variations in the LTC4S gene have been associated with increased susceptibility to asthma and other inflammatory diseases.
Yes, there are drugs targeting LTC4S protein, such as leukotriene modifiers, which are used to manage asthma and allergic rhinitis.
LTC4S protein levels in blood or sputum samples have been investigated as potential biomarkers for asthma severity and response to treatment.
Customer Reviews (3)
Write a reviewThe LTC4S Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.
Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.
In addition to its remarkable quality and exceptional technical support, the LTC4S Protein boasts an impressive range of applications.
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