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LDHA

  • Official Full Name

    lactate dehydrogenase A

  • Overview

    The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
  • Synonyms

    LDHA; lactate dehydrogenase A; LDH1; LDHM; GSD11; PIG19; HEL-S-133P; L-lactate dehydrogenase A chain; LDH-A; LDH-M; LDH muscle subunit; lactate dehydrogenase M; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59; cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Staphylococcus Aureus
  • Zebrafish
  • Chicken
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Erythrocyte
  • Human Heart
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LDH1-219H Active Native Human Lactate Dehydrogenase 1 Human Heart N/A
Human LDHA-262H Active Recombinant Human LDHA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LDHA-494HFL Active Recombinant Full Length Human LDHA Protein, C-Flag-tagged Mammalian cells Flag
Human LDH1-218H Active Native Human Lactate Dehydrogenase 1 Human Erythrocyte N/A
Human LDHA-1944H Recombinant Human Lactate dehydrogenase A, His-tagged E.coli His
Human LDHA-29849TH Active Recombinant Human LDHA Protein, His-tagged E.coli His
Human LDHA-261H Recombinant Human LDHA, GST-tagged Wheat Germ GST
Human LDHA-4790HCL Recombinant Human LDHA 293 Cell Lysate HEK293 N/A
Human LDHA-3158H Recombinant Human LDHA protein E.coli N/A 5-323aa
Human LDHA-26867TH Native Human LDHA N/A
Human LDHA-6967HF Recombinant Full Length Human LDHA Protein, GST-tagged In Vitro Cell Free System GST 332 amino acids
Human LDHA-30120H Recombinant Human LDHA protein, GST-tagged E.coli GST Ile283-Phe332
Human LDHA-1284H Recombinant Human LDHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LDHA-3157H Recombinant Human LDHA protein, His-tagged E.coli His 5-323aa
Human LDHA-0136H Recombinant Human LDHA Protein (A2-F332), His tagged E.coli His A2-F332
Human LDHA-0135H Recombinant Human LDHA Protein (A2-F332), Tag Free E.coli No tag A2-F332
Human LDHA-4429H Recombinant Human LDHA Protein (Met1-Phe332), N-His tagged E.coli N-His Met1-Phe332
Human LDHA-1284H-B Recombinant Human LDHA Protein Pre-coupled Magnetic Beads HEK293
Mouse Ldha-61M Active Recombinant Mouse Ldha Protein, His-tagged Insect Cell His
Mouse Ldha-1000M Active Recombinant Mouse Ldha protein(Met1-Phe332), His-tagged E. coli N-His Met1-Phe332
Mouse Ldha-5712M Recombinant Mouse Ldha Protein (Met1-Phe332), C-His tagged Mammalian cells C-His Met1-Phe332
Mouse Ldha-1305M Recombinant Mouse Ldha Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ldha-7252M Active Recombinant Mouse Ldha Protein, His-tagged His 1-332
Rat Ldha-1131R Active Recombinant Rat LDHA protein(Met1-Phe332), His-tagged E. coli N-His Met1-Phe332
Rhesus Macaque LDHA-2486R Recombinant Rhesus monkey LDHA Protein, His-tagged Mammalian Cell His
Rhesus Macaque LDHA-2307R Recombinant Rhesus Macaque LDHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LDHA-2307R-B Recombinant Rhesus Macaque LDHA Protein Pre-coupled Magnetic Beads HEK293
Staphylococcus Aureus LDHA-1914S Recombinant Staphylococcus Aureus LDHA Protein (1-317 aa), His-SUMO-tagged E.coli His/SUMO 1-317 aa
Zebrafish LDHA-8843Z Recombinant Zebrafish LDHA Mammalian Cell His
Pig LDHA-6873P Recombinant Pig LDHA protein, His & GST-tagged E.coli His/GST Met1~Phe332 (Accession # P00339)
Chicken LDHA-6836C Recombinant Chicken LDHA Mammalian Cell His
Chicken LDHA-8315C Native Chicken LDHA Chicken N/A
Chicken LDHA-0012C Recombinant Chicken LDHA Protein (Full Length), N-His-tagged E.coli N-His Full Length
Kit-2370 Human Lactate Dehydrogenase A Inhibitor Screening Kit (Colorimetric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LDHA Related Articles
  • LDHA Related Research Area

LDHA involved in several pathways and played different roles in them. We selected most pathways LDHA participated on our site, such as Glycolysis / Gluconeogenesis, Cysteine and methionine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisALDOAB;TPI1;GAPDH;ENO1A;LDHAL6B;ENO3;LDHBA;GPIA;ACSS1
Cysteine and methionine metabolismGOT1;GOT2;AHCYL1;MDH1;MAT2AA;MAT2AB;LDHAL6A;SRM;DNMT3AA
Pyruvate metabolismME1;GRHPRA;PDP2;ACYP1;ACSS1;LDHC;MDH2;GRHPRB;PDHA1A
Propanoate metabolismMLYCD;ACACB;MUT;LDHA;HADHAB;SUCLG1;LDHAL6A;LDHAL6B;LDHB
Metabolic pathwaysGBA3;SGMS1;B4GALT3;CNDP2;BHMT;COQ7;MTMR7A;FH1;PKM2
HIF- signaling pathwayEIF4E2;NOS3;ANGPT1;HK3;CAMK2D;IFNGR2;PDHA1;PIK3R2;MKNK2
Central carbon metabolism in cancerPIK3CD;RAF1;GLS2;FGFR1;GLS;PDHA1;KRAS;MAP2K2;SLC2A2

LDHA has several biochemical functions, for example, L-lactate dehydrogenase activity, NAD binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDHA itself. We selected most functions LDHA had, and list some proteins which have the same functions with LDHA. You can find most of the proteins on our site.

Function Related Protein
L-lactate dehydrogenase activityLDHAL6A;LDHBA;LDHB;LDHC;LDHA;LDHAL6B;LDHBB
NAD bindingHADHA;GAPDH;BDH2;NNT;SORD;LDHB;ME3;IDH1;NDUFV1
identical protein bindingBCAT1;ATF3;PYDC3;S100A4;SIAH1;MICU1;SDK2;LZTFL1;GDF5
kinase bindingPRKAA1;PARK7;PFKFB1;DUSP12;PRDX3;PPP2R5A;MIDN;TENC1;WWC2
protein bindingABCD1;EIF3J;MEAF6;CCDC137;MT1G;HIF1A;SEMA4A;ISL1;STIM2

LDHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDHA here. Most of them are supplied by our site. Hope this information will be useful for your research of LDHA.

HSPA8; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; pyruvate; nadh; YWHAZ; TFAP2A; LDHB; TERF1; hpaX; dppC3; ydaJ; XRN1; metE

Yip, SSM; Zhou, MX; et al. Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells. MOLECULAR BIOTECHNOLOGY 56:833-838(2014).
Grimm, M; Cetindis, M; et al. Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
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