LGALS9
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Official Full Name
lectin, galactoside-binding, soluble, 9
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Overview
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkins disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
LGALS9; lectin, galactoside-binding, soluble, 9; galectin-9; galectin 9; LGALS9A; Ecalectin; Gal-9; galectin9; HOM HD 21; HOM-HD-21; HOMHD21; HUAT; Lectin galactoside binding soluble 9; Lectin galactoside-binding soluble 9; LEG9_HUMAN; LGAL S9; LGALS 9; MGC117375; MGC125973; MGC125974; Tumor antigen HOM-HD-21; Urate transporter/channel protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Antibody
- Cattle
- Dog
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Human cells
- Mammalian Cell
- Mammalian cells
- Rat
- Yeast
- Fc
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- N
- PE
- Involved Pathway
- Protein Function
- Interacting Protein
- LGALS9 Related Articles
- LGALS9 Related Research Area
LGALS9 involved in several pathways and played different roles in them. We selected most pathways LGALS9 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interleukin-2 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGALS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | CSK;TRIM22;RASGRP1;IFIT11;IL17RD;FGF8B;DUSP1;PAQR3B;TNFSF13B |
| Immune System | ASB3;SEC24A;CD300E;TXNIPB;KPNA5;EDAR;TRIM56;CFHL1;RACGAP1 |
| Interleukin-2 signaling | LGALS9;HAVCR2 |
| Signaling by Interleukins | HAVCR2;SOCS3A;LGALS9;CASPB;IL1RN;CASPBL |
LGALS9 has several biochemical functions, for example, carbohydrate binding, disaccharide binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LGALS9 itself. We selected most functions LGALS9 had, and list some proteins which have the same functions with LGALS9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | KLRB1;CLEC14A;REG1A;LMAN1L;GFPT1;KLRB1B;CLEC19A;GALNTL1;CNTN1 |
| disaccharide binding | |
| enzyme binding | ZFP346;ATXN10;SNRPD3;PEX7;PRTN3;PARK7;WWOX;HDAC6;PARK2 |
| galactose binding | COLEC12;ENG;CLEC4F;GALK1;LGALS9 |
| signal transducer activity | OMP;AXIN1;TAAR10D;PPFIA1;GNG13A;GNAI2;GNRHR1;TRIM38;DRD7 |
LGALS9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGALS9 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGALS9.
rlmL; q7ard3_yerpe; fhaB4; atoC; q7cji6_yerpe; acoB; malS; q81xz0_bacan; fimD7; syd; cheY; bioD1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are clinical trials investigating the use of LGALS9-based therapies in cancer treatment, with a focus on immunotherapy approaches.
There is emerging research on the potential use of LGALS9 in modulating immune responses to infectious diseases, particularly in the context of viral infections.
Challenges include optimizing the delivery and dosing of LGALS9-based therapies and addressing potential adverse effects on immune homeostasis.
LGALS9 is being investigated for its potential to induce immune tolerance and mitigate transplant rejection in preclinical studies.
LGALS9 has been found to promote the activation and proliferation of cytotoxic T lymphocytes, which are key players in the immune response against cancer cells.
Customer Reviews (3)
Write a reviewIt has demonstrated outstanding performance in ELISA, providing reliable and precise results.
It has been invaluable in protein electron microscopy structure analysis, facilitating detailed investigations and yielding valuable insights.
I highly recommend the LGALS9 protein for various experimental applications.
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