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PNLIP

  • Official Full Name

    pancreatic lipase

  • Overview

    Pancreatic lipase, also known as pancreatic triacylglycerol lipase, is secreted from the pancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Triacylglycerol + H2O diacylglycerol + a fatty acid anion Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This protein belongs to pancreatic lipase family.
  • Synonyms

    PNLIP; pancreatic lipase; PL; PTL; pancreatic triacylglycerol lipase; OTTHUMP00000020564; triacylglycerol acylhydrolase; Lipase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Pancreas
  • In Vitro Cell Free System
  • Mammalian Cell
  • Porcine Pancreas
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PNLIP-30776TH Recombinant Human PNLIP Wheat Germ N/A 465 amino acids
Human PNLIP-8599H Recombinant Human PNLIP, His-tagged HEK293 His Met1-Cys465
Human PNLIP-1246HCL Recombinant Human PNLIP cell lysate Human Cell N/A
Human PNLIP-13H Recombinant human pancreatic lipase Reference Standard N/A
Human PNLIP-2603H Recombinant Human PNLIP Protein, His-tagged E.coli N-His Pro245-Cys465
Human PNLIP-12H Human pancreatic lipase from pancreatic juice Reference Standard N/A
Human PNLIP-8203H Native Human Pancreatic Lipase Human Pancreas N/A
Human PNLIP-28H Recombinant Human PNLIP Protein, N-His Tagged E.coli N-His
Human PNLIP-2415H Recombinant Human PNLIP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PNLIP-8205H Native Human Pancreas Lipase Human Pancreas N/A
Human PNLIP-375HF Recombinant Full Length Human PNLIP Protein In Vitro Cell Free System 465 amino acids
Mouse Pnlip-1331M Recombinant Mouse Pnlip Protein, His-SUMO-tagged E.coli His/SUMO
Mouse Pnlip-6977M Recombinant Mouse Pnlip protein, His & T7-tagged E.coli His/T7 Gly201~Leu412 (Accession # Q6P8U6)
Mouse Pnlip-4964M Recombinant Mouse Pnlip Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PNLIP-4545R Recombinant Rat PNLIP Protein Mammalian Cell His
Rat Pnlip-26R Recombinant Rat Pnlip protein, His-tagged E.coli His Ser47~His280
Rat PNLIP-4205R-B Recombinant Rat PNLIP Protein Pre-coupled Magnetic Beads HEK293
Rat PNLIP-4205R Recombinant Rat PNLIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig PNLIP-1175P Native Porcine Pancreatic Lipase Porcine Pancreas N/A
Chicken PNLIP-4795C Recombinant Chicken PNLIP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PNLIP Related Articles

PNLIP involved in several pathways and played different roles in them. We selected most pathways PNLIP participated on our site, such as Glycerolipid metabolism, Metabolic pathways, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerolipid metabolismPNLIP;GLYCTK;Akr1b3;DAK;TAE1;AKR1A1;DGAT1A;ALDH3A2A;DGKB
Metabolic pathwaysPDHA1B;ENPP7;IMPDH2;GOT2;SPTLC3;GPT2;PLA2G4AA;CEPT1B;DNMT3A
Pancreatic secretionCELA2B;SLC26A3;CPB1;ATP2B1;Slc4a2;PRSS2;ATP1A2;CLCA4;TPCN2
Fat digestion and absorptionPLA2G10;DGAT2;PLA2G2D;DGAT1;PLA2G2A;GOT2;PLA2G1B;PNLIPRP1;ABCA1
Vitamin digestion and absorptionTCN2;APOB;SLC52A3;MMACHC;FOLH1;APOA4;PNLIP;CUBN;RBP2

PNLIP has several biochemical functions, for example, metal ion binding, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNLIP itself. We selected most functions PNLIP had, and list some proteins which have the same functions with PNLIP. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZNF70;RXRGA;YOD1;MORC2B;ZNFX1;ATP2B1;ZNF10;EXOG;ZFP260
triglyceride lipase activityPNPLA3;PNPLA4;CES5A;AADAC;LIPC;CES1;PNLIPRP3;PNPLA2;LPL

PNLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNLIP.

CLPS; YWHAE

Hachero-Cruzado, I; Rodriguez-Rua, A; et al. Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 12:61-73(2014).
Behar, DM; Basel-Vanagaite, L; et al. Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency. JOURNAL OF LIPID RESEARCH 55:307-312(2014).
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