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LRIG1

Official Full Name

leucine-rich repeats and immunoglobulin-like domains 1
Overview

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family, METand RET.
Synonyms

LRIG1; leucine-rich repeats and immunoglobulin-like domains 1; leucine-rich repeats and immunoglobulin-like domains protein 1; DKFZP586O1624; leucine rich repeat protein LRIG1; LIG 1; LIG1; ortholog of mouse integral membrane glycoprotein LIG 1; Leucine rich repeat protein; leucine rich repeats and immunoglobulin like domains 1; LIG-1; LRIG1_HUMAN; OTTHUMP00000213345; OTTHUMP00000213346; leucine-rich repeat protein LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1;

Type

Protein Pre-coupled Magnetic Beads
Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Human Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|T7
Myc
DDK
MYC
Myc|DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LRIG1-1316H-B	Recombinant Human LRIG1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	LRIG1-1337HFL	Recombinant Full Length Human LRIG1 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	LRIG1-4183H	Recombinant Human LRIG1 Protein (Cys45-Val397), N-His tagged	E.coli	N-His	Cys45-Val397	Inquiry
Human	LRIG1-850H	Recombinant Human LRIG1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	LRIG1-1316H	Recombinant Human LRIG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	LRIG1-1878H	Recombinant Human LRIG1 protein, His & T7-tagged	E.coli	His/T7	His739~Leu995 (Accession # Q96JA1)	Inquiry
Human	LRIG1-5678H	Recombinant Human LRIG1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Lrig1-6980M	Recombinant Mouse Lrig1 protein, His-tagged	HEK293	His	Met1-Thr794	$498 / 20 µg
Mouse	LRIG1-1828MCL	Recombinant Mouse LRIG1 cell lysate	Human Cell	N/A		Inquiry
Mouse	Lrig1-1249M	Recombinant Mouse Lrig1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LRIG1 Related Articles
LRIG1 Related Research Area

LRIG1 involved in several pathways and played different roles in them. We selected most pathways LRIG1 participated on our site, such as Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signal Transduction	CHRDL1;DTX2;TULP3;IQGAP3;RTN4;SRY;AMOTL2B;STRA6;RGS1
Signaling by EGFR	LRIG1;PTPRK;ADAM12;SPRY1;PAG1

LRIG1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by LRIG1 itself. We selected most functions LRIG1 had, and list some proteins which have the same functions with LRIG1. You can find most of the proteins on our site.

Function	Related Protein

LRIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRIG1.

Poulin, EJ; Powell, AE; et al. Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine. STEM CELL RESEARCH 13:422-430(2014).

Oh, YM; Lee, SB; et al. USP8 modulates ubiquitination of LRIG1 for Met degradation. SCIENTIFIC REPORTS 4:-(2014).

EGF Ligands

Epidermal Growth Factor (EGF)