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MACF1

  • Official Full Name

    microtubule-actin crosslinking factor 1

  • Overview

    The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family;forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one;of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule;binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may;function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the;microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have;been described.
  • Synonyms

    MACF1; microtubule-actin crosslinking factor 1; microtubule-actin cross-linking factor 1; ABP620; Acf7; Aclp7; Actin cross linking family 7; MACF; Microtubule actin crosslinking factor 1; mKIAA0465; R74989; rabeculin alpha; trabeculin alpha; actin cross-linking family 7; actin-crosslinking protein 7;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MACF1-681H Recombinant Human MACF1, GST-tagged E.coli GST C-term-303aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MACF1 Related Articles

MACF1 involved in several pathways and played different roles in them. We selected most pathways MACF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MACF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MACF1 has several biochemical functions, for example, ATPase activity, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MACF1 itself. We selected most functions MACF1 had, and list some proteins which have the same functions with MACF1. You can find most of the proteins on our site.

Function Related Protein
ATPase activityHSPA5;NSFB;ABCA1B;KIF3CB;DDX3X;ABCD3;HSPA1B;PSMC1;KIF9
actin bindingVCL;VASP;ADD2;FSCN1;ABRA;SCIN;FBXO25;SSH2;SHROOM4
actin filament bindingMYO6;MYO1A;ACTN2;ACTN1;LIMA1;VIL1;VCLA;MYO18A;ABL2
calcium ion bindingLTBP3;RASGRP3;CDH12A;MYLZ3;CD93;PCDHB7;MYLPF;FLG;NELL1
microtubule bindingDPYSL2B;PPP5C;VPS41;MTAP1B;CLIP3;CEP57;KIF3CB;SKA2;DPYSL5A
poly(A) RNA bindingRBM27;TRMT2A;HUWE1;EEF2;SLBP;XRCC5;HNRNPU;RPL7A;WDR36
protein bindingFRMD7;HIST1H4B;RPS3A;CHMP1B;SRA1;HPRT1;CBX5;TTPA;HMGB4

MACF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MACF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MACF1.

VCAM1; 40038273; RAB21; SAP18; MPG; RAB21; JUN; SKIL; APC; MAPK9; ATF7IP; pyrG; q81n36_bacan; q81si6_bacan; DTNBP1; DISC1

Lu, S; Tian, ZC; et al. Preparation and characterization of the polyclonal antibody against GAR domain of microtubule actin cross-linking factor 1 (MACF1). AFRICAN JOURNAL OF BIOTECHNOLOGY 10:2156-2162(2011).
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