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MAD2

Official Full Name

mitotic arrest deficient 2
Overview

MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. hMAD2 is the human homologue of yeast MAD2.
Synonyms

HSMAD2; Human mitotic feedback control protein Madp2 homolog mRNA complete cds; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2B; MAD2L1; Mitotic arrest deficient 2; Mitotic spindle assembly checkpoint protein MAD2A; REV7; mitotic arrest deficient 2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
	CBCRY02	Mitotic arrest deficient 2	E.coli	N/A		Inquiry

MAD2 Related Articles
MAD2 Related Gene Family

MAD2 involved in several pathways and played different roles in them. We selected most pathways MAD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MAD2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MAD2 itself. We selected most functions MAD2 had, and list some proteins which have the same functions with MAD2. You can find most of the proteins on our site.

Function	Related Protein

MAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD2.

Xia, P; Wang, ZK; et al. EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:16564-16569(2012).

Nakano, Y; Sumi, T; et al. Expression of the mitotic-arrest deficiency 2 is associated with chemotherapy resistance in ovarian serous adenocarcinoma. ONCOLOGY REPORTS 28:1200-1204(2012).