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MAD2L2

  • Official Full Name

    MAD2 mitotic arrest deficient-like 2

  • Overview

    The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
  • Synonyms

    MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast); MAD2 (mitotic arrest deficient, yeast, homolog) like 2; mitotic spindle assembly checkpoint protein MAD2B; MAD2B; mitotic arrest deficient homolog like 2; REV7; hREV7; REV7 homolog; MAD2-like protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAD2L2-683H Recombinant Human MAD2L2, GST-tagged E.coli GST 2-211aa
Human MAD2L2-4567HCL Recombinant Human MAD2L2 293 Cell Lysate HEK293 N/A
Human MAD2L2-685H Recombinant Human MAD2L2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAD2L2-2787H Recombinant Human MAD2L2 protein, His-tagged E.coli His 2-211 aa
Human MAD2L2-3376H Recombinant Human MAD2L2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Mad2l2-3897M Recombinant Mouse Mad2l2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAD2L2-3528R Recombinant Rat MAD2L2 Protein Mammalian Cell His
Rat MAD2L2-3184R-B Recombinant Rat MAD2L2 Protein Pre-coupled Magnetic Beads HEK293
Rat MAD2L2-3184R Recombinant Rat MAD2L2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAD2L2-2620R Recombinant Rhesus monkey MAD2L2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAD2L2-2440R Recombinant Rhesus Macaque MAD2L2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAD2L2-2440R-B Recombinant Rhesus Macaque MAD2L2 Protein Pre-coupled Magnetic Beads HEK293
Chicken MAD2L2-2212C Recombinant Chicken MAD2L2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MAD2L2 involved in several pathways and played different roles in them. We selected most pathways MAD2L2 participated on our site, such as Bacterial invasion of epithelial cells, Cell cycle, DNA Damage Bypass, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD2L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bacterial invasion of epithelial cellsARPC2;PIK3CD;ILK;CTNNA2;SHC2;CTNNA1;SEPT11;SHC4;ELMO1
Cell cycleCDKN2C;PLK4;CDC25A;DYNC1I2;SMAD3;TGFB3;SMC2;ORC5;STAG2A
DNA Damage BypassMAD2L2;KIAA0101;SPRTN;USP43A;USP10;DDB1;POLI;ZBTB32;DTL
DNA RepairCHEK2;ZBTB32;RAD51AP1;PPP4CA;APITD1;RNF4;THRSP;TFPT;CETN2
Oocyte meiosisPPP2R5EA;STAG3;PPP1R2P9;PRKACBB;PPP2CA;PPP3CC;IGF1R;CTH1;RPS6KA3
Progesterone-mediated oocyte maturationRPS6KA2;MAPK1;SPDYA;GNAI1;CDC16;ANAPC7;PIK3R3B;MAPK9;CPEB4
ShigellosisMAPK3;UBE2D2;NFKB1;MAPK9;MAPK13;PFN4;WASF1;RIPK2;VCL
Translesion synthesis by POLIMAD2L2;POLI

MAD2L2 has several biochemical functions, for example, JUN kinase binding, RNA polymerase II activating transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAD2L2 itself. We selected most functions MAD2L2 had, and list some proteins which have the same functions with MAD2L2. You can find most of the proteins on our site.

Function Related Protein
JUN kinase bindingSPAG9A;MAPK8IP3;PTK2;SPAG9;MAD2L2;GSTP1
RNA polymerase II activating transcription factor bindingEOMES;BHLHE40;NFE2L2;POU1F1;ATF2;BEX1;SETD3;NEUROD1;TBX6
protein bindingPDGFA;ZBTB6;KCNQ4;CTGF;USP12;LSM6;ZNF460;IFNGR1;KIAA1958

MAD2L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD2L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD2L2.

CHAMP1; REV3L; ADAM9; ipaB; SFI1

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