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MAGEA8

  • Official Full Name

    melanoma antigen family A, 8

  • Overview

    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    MAGEA8; melanoma antigen family A, 8; MAGE8; melanoma-associated antigen 8; cancer/testis antigen family 1; member 8; CT1.8; MAGE 8 antigen; MGC2182; MAGE8 antigen; Melanoma antigen family A 8; Melanoma associated antigen 8; MAGE-8 antigen; OTTHUMP00000024218; cancer/testis antigen 1.8; cancer/testis antigen family 1, member 8;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAGEA8-28418TH Recombinant Human MAGEA8, His-tagged E.coli His
Human MAGEA8-4550HCL Recombinant Human MAGEA8 293 Cell Lysate HEK293 N/A
Human MAGEA8-1343H Recombinant Human MAGEA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAGEA8-1608HFL Recombinant Full Length Human MAGEA8 Protein, C-Flag-tagged Mammalian cells Flag
Human MAGEA8-1343H-B Recombinant Human MAGEA8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAGEA8 Related Articles

MAGEA8 involved in several pathways and played different roles in them. We selected most pathways MAGEA8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGEA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MAGEA8 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEA8 itself. We selected most functions MAGEA8 had, and list some proteins which have the same functions with MAGEA8. You can find most of the proteins on our site.

Function Related Protein
molecular_functionBRD2A;CCDC46;CEP55L;LRRC55;CRYGM2D1;DEFA3;SHISA6;PRL8A9;TMEM144
protein bindingZNF821;BLMH;RRS1;ZC4H2;APOB;FBXO18;ZBTB17;ADAM10;PIK3R6

MAGEA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEA8.

BEX5; MAGEB4; LMO2; GCA; PKD2; MTUS2; LXN

Zhang, QM; He, SJ; et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3918-3927(2014).
Morgan, RA; Chinnasamy, N; et al. Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy. JOURNAL OF IMMUNOTHERAPY 36:133-151(2013).
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