The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of;proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein;in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous;system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation,;stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has;been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript;variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.