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MAP3K13

Official Full Name

mitogen-activated protein kinase kinase kinase 13
Overview

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
Synonyms

MAP3K13; mitogen-activated protein kinase kinase kinase 13; leucine zipper bearing kinase; LZK; MEKK13; mixed lineage kinase; leucine zipper-bearing kinase; MLK; MGC133196;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Insect (sf21)
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K13-1055HCL	Recombinant Human MAP3K13 cell lysate		N/A		Inquiry
Human	MAP3K13-1940HF	Active Recombinant Full Length Human MAP3K13 Protein, GST-tagged	Insect (sf21)	GST	1-966	Inquiry
Human	MAP3K13-3713H	Recombinant Human MAP3K13 protein, GST-tagged	E.coli	GST	706 - 839 aa	$319 / 25ug
Mouse	MAP3K13-9509M	Recombinant Mouse MAP3K13 Protein	Mammalian Cell	His		Inquiry
Mouse	MAP3K13-5330M-B	Recombinant Mouse MAP3K13 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MAP3K13-5330M	Recombinant Mouse MAP3K13 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAP3K13 Related Articles

MAP3K13 involved in several pathways and played different roles in them. We selected most pathways MAP3K13 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	CASP3B;MAP2K2A;GRB2;NFKB1;MAP2K5;MAP3K2;RRAS2;SOS1;TMEM37

MAP3K13 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K13 itself. We selected most functions MAP3K13 had, and list some proteins which have the same functions with MAP3K13. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	PEX1;NLRP9C;ACVR1B;SPEG;EPHA2A;MYO3A;CLK2A;HSP70;DHX8
MAP kinase kinase kinase activity	MAP3K5;MAP3K13;MAP3K3;MAP3K6;STK4;MAP3K1;MAP3K4;MAP3K15;MOS
identical protein binding	PSME3;GOT1L1;GRIN3A;LYZ;ROBO1;KCNRG;ALDOB;SCUBE1;L1CAM
metal ion binding	ZBTB49;MUL1A;ZBTB41;ZBTB16A;ZC3H18;JADE1;ZNF652;ZNF668;ZDHHC16A
protein binding	WDR25;MYRIP;FOXL2;KLRK1;ATP6V1E2;LMO1;NOL6;APOA2;CACNB4
protein homodimerization activity	DCK;CHKA;ABCB10;PEX7;ADIPOQ;AGR2;LRRFIP1;HRSP12;CHEK2
protein kinase binding	TPCN2;ACSL3;CENPJ;MAPK6;LAT;BAG5;ZFP36;PRKCZ;ARHGEF7
protein serine/threonine kinase activity	PRKACBB;PRKCI;ADCK4;ULK1A;TRPM6;DCKL1B;SMOK3B;PBK;PAK2B

MAP3K13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K13.

STAT3; HLA-DRB3; GLO1

Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).

Mongkhon, JM; Thach, M; et al. Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. INFLAMMATION RESEARCH 63:691-701(2014).