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MAPK11

  • Official Full Name

    mitogen-activated protein kinase 11

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms

    MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK11-122HFL Unactive Recombinant Full Length Human MAPK11 Protein, N-GST-tagged E. coli GST Full Length
Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His 364 amino acids
Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
Human MAPK11-1084H Recombinant Human MAPK11 Protein (S2-Q364), Tag Free Insect Cell No tag S2-Q364
Human MAPK11-2038HF Active Recombinant Full Length Human MAPK11 Protein, GST-tagged E.coli GST 1-364
Human MAPK11-1085H Recombinant Human MAPK11 Protein (S2-Q364), GST tagged Insect Cell GST S2-Q364
Human MAPK11-4996H Recombinant Human MAPK11 Protein (Leu24-Phe308), N-His tagged E.coli N-His Leu24-Phe308
Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
Mouse MAPK11-5344M Recombinant Mouse MAPK11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAPK11-5344M-B Recombinant Mouse MAPK11 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His
Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK11 Related Articles
  • MAPK11 Related Research Area
  • MAPK11 Related Signal Pathway

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPP3CC;IKBKG;FGF18A;RASGRP3;JUND;MAP2K3;FGF7;MAPK8IP2;SRFA
Rap signaling pathwayACTB;RASSF5;PRKCA;LPAR5;FIGF;FGF21;RAP1B;GNAI3;THBS1
FoxO signaling pathwayGADD45B;TGFB1A;STAT3;GRB2A;PCK1;PDPK1;PTENA;MAPK14A;G6PCA.2
Sphingolipid signaling pathwayMAP2K2;MAP3K5;PRKCZ;PPP2R5B;PLD2;MAPK9;GNAI1;KRAS;PPP2R2A
Adrenergic signaling in cardiomyocytesPPP2R5B;RPS6KA5;ADRB2A;GNA15.1;PRKACAB;CACNG2;ATP1B3;ATF2;MAPK12
VEGF signaling pathwayPRKCBB;CDC42L2;MAPK3;MAPK12;PPP3CC;VEGFA;PTK2AB;PLCG1;MAPK1
Osteoclast differentiationMAPK1;MAP2K7;CSF1R;MAP2K1;PIK3R2;IKBKB;SOCS3;MAP3K7;NOX1
Signaling pathways regulating pluripotency of stem cellsFZD8;PCGF6;PIK3R2;SMARCAD1;FZD6;Fzd4;BMI1;KLF4;WNT7A
Platelet activationSRC;TBXA2R;TLN1;ARHGAP35;MAPK11;PIK3CB;MYLK4;PPP1CB;ORAI1
Toll-like receptor signaling pathwayMAPK11;NFKBIAA;TRAF3;RIPK1L;MAP2K4A;IFNB;PIK3R3;IFNA2;MAPK14A
NOD-like receptor signaling pathwayTAB2;PSTPIP1B;CARD9;PYDC1;SUGT1;IL1B;NLRP3;BIRC2;NFKBIB
RIG-I-like receptor signaling pathwaySIKE1;PL10;IL12BA;IL-8;IFIH1;IFNA17;RNF125;PIN1;MAPK8A
T cell receptor signaling pathwayPPP3CC;NFKBIB;GSK3B;RAF1;NCK2;PIK3CB;MAP2K1;PDCD1;LCK
Fc epsilon RI signaling pathwayGRB2;LCP2;PIK3R1;PIK3R5;MS4A2;PIK3CB;LYN;IL4;MAP2K7
TNF signaling pathwayMAPK13;SOCS3;NFKB1;AKT2;MAPK12;TRAF2;NFKBIA;CXCL1;CREB3L2
Leukocyte transendothelial migrationACTN3;CLDN23;ACTN4;F11R;CLDN15;NOX1;ICAM1;CLDN18;PLCG2
Neurotrophin signaling pathwayMAPK1;PRKCD;NTF4;MAPK9;YWHAE;Fasl;PLCG2;MAP3K1;NFKBIA
Retrograde endocannabinoid signalingMAPK8;PRKACA;GABRA6;PRKACB;GNB3;GNG2;GNG4;GRM1;GNG5
Dopaminergic synapseCREB3L4;PPP2R2D;GNAI2;TH;DDC;GNGT1;SCN1A;PPP3CA;PLCB1
Inflammatory mediator regulation of TRP channelsIL1RAP;CYP2C70;CALM2;CALM3;TRPV2;PTGER4;PRKCB;NTRK1;MAPK13
GnRH signaling pathwayGNRHR4;MAP3K4;PTK2B;ADCY1A;ITPR1;PRKCBA;PLCB4;LHBETA1;MAPK14A
Progesterone-mediated oocyte maturationCCNB1;RPS6KA3B;PGR;ANAPC2;CPEB1A;PIK3CB;SPDYA;MAPK14B;MAPK12B
Prolactin signaling pathwayKRAS;SHC1;MAPK1;SHC3;PIK3R2;MAPK9;PRL;LHCGR;MAPK3
Amyotrophic lateral sclerosis (ALS)CASP9;MAPK14;PPP3R2;MAP3K5;PRPH;DAXX;PPP3CC;GRIA2;GRIN2C
Epithelial cell signaling in Helicobacter pylori infectionCXCL1;ATP6V1C2;MAPK10;NFKB1;RAC1;ATP6AP1;IL-8;MAPK13;MAP2K4
ShigellosisWASF1;NFKB1;ROCK2;ARPC5L;MAPK8;UBE2D2;ACTB;ELMO1;RIPK2
Salmonella infectionWASB;MAPK1;ROCK1;RAB7B;ARPC5B;TLR4;IFNG;ARPC5L;CD14
PertussisIL6;TNF;C1RA;C3;IRAK1;NLRP3;C4A;MAPK8;ITGB2L
LeishmaniasisFOS;IL12B;IFNG;MAPK12;HLA-DMA;IFNGR2;IL4;IL1B;CR1
Chagas disease (American trypanosomiasis)TLR4;TLR9;IRAK4;TRAF6;TGFB2;TGFB3;CFLAR;C3;NFKBIA
ToxoplasmosisNFKBIB;MAPK3;SOCS1;IKBKB;LAMA4;TNFRSF1A;TLR2;H2-AB1;HSPA2
TuberculosisCD209B;IRAK2;ATP6V0D2;IFNA6;FCGR3A;NOS2;RAB7;IFNA5;NFKB1
Hepatitis CTBK1;PPP2R2C;IFNAR1;MAPK3;KRAS;IFNA7;MAPK10;BAD;IFNA21
Influenza AAKT1;IL8L2;HSPA8;TNFRSF10A;FDPS;AKT2;MYD88;HLA-DRB5;MAPK9
Epstein-Barr virus infectionCR2;MAPK11;PIK3CB;IKBKB;TAB1;ITGAL;PLCG2;YWHAH;PTMA
Proteoglycans in cancerPIK3CD;FN1;SDC2;WNT2;HGF;MRAS;FZD2;ARHGEF1;GPC1

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYLK;PL10;RPS6KA3A;MYO18A;SMYHC2;ENTPD8;NLK1;CAMK1D;PPP1CA
MAP kinase activityMAPK14;MAPK8B;MAPK7;NLK2;MAPK14A;MAPK12A;MAPK11;MAPK3;MAPK15
protein bindingCCK;DTX1;PHOSPHO2-KLHL23;WBP2NL;ARHGDIG;MCM6;AP5Z1;JOSD1;RNF168
protein serine/threonine kinase activityPRKACAA;PRKCHB;SMG1;RAF1;BMPR2B;STK35;MAPK6;CSNK1D;PRKCA

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.

MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
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