MAPK11

Official Full Name

mitogen-activated protein kinase 11

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.

Synonyms

MAPK11; mitogen-activated protein kinase 11; Human p38Beta MAP kinase mRNA complete cds; MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mitogen activated protein kinase 11; Mitogen activated protein kinase p38 beta; Mitogen-activated protein kinase p38 beta; MK11_HUMAN; p38 2; p38-2; p38B; p38Beta; P38BETA2; PRKM11; Protein kinase mitogen activated 11; SAPK2; SAPK2B; Stress activated protein kinase 2; Stress-activated protein kinase 2; protein kinase, mitogen activated kinase, 11, p38beta