Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

MAPK3

  • Official Full Name

    MAPK3 mitogen-activated protein kinase 3

  • Synonyms

    MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK3-28699TH Recombinant Human MAPK3 E.coli N/A 378 amino acids
Human MAPK3-1031M Recombinant Human MAPK3 protein E.coli N/A Full Length
Human MAPK3-28H Recombinant human biotinylated ERK1, His-tagged E.coli His
Human MAPK3-34H Recombinant Human MAPK3 E.coli N/A
Human MAPK3-36H Recombinant Human MAPK3 E.coli N/A
Human MAPK3-1048H Recombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged E.coli GST
Human MAPK3-28694TH Recombinant Human MAPK3 E.coli N/A 379 amino acids
Human MAPK3-287H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP 146-210 aa
Human MAPK3-2787H Recombinant Human MAPK3, His-tagged E.coli His
Human MAPK3-1049H Recombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged E.coli GST
Human MAPK3-286H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP 246-360 aa
Human MAPK3-1517H Recombinant Human MAPK3 protein E.coli N/A
Human MAPK3-288H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP 12-84 aa
Human MAPK3-307H Active Recombinant Human MAPK3 Protein E.coli
Human MAPK3-4494HCL Recombinant Human MAPK3 293 Cell Lysate HEK293 N/A
Human ERK1-125H Recombinant Human MAPK3 protein, His-tagged E.coli His 238
Human MAPK3-061H Recombinant Human MAPK3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MAPK3-1050H Active Recombinant Human MAPK3 Protein, His/GST-Tagged E. coli His&GST
Human MAPK3-2068HF Active Recombinant Full Length Human MAPK3 Protein, GST-tagged E.coli GST 1-379
Human MAPK3-1363H Recombinant Human MAPK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAPK3-635HFL Recombinant Full Length Human MAPK3 Protein, C-Flag-tagged Mammalian cells Flag
Human MAPK3-1363H-B Recombinant Human MAPK3 Protein Pre-coupled Magnetic Beads HEK293
Human MAPK3-1082H Recombinant Human MAPK3 Protein (A2-P379), Tag Free E.coli No tag A2-P379
Human MAPK3-1083H Recombinant Human MAPK3 Protein (A2-P379), GST tagged E.coli GST A2-P379
Mouse MAPK3-9534M Recombinant Mouse MAPK3 Protein Mammalian Cell His
Mouse MAPK3-5350M-B Recombinant Mouse MAPK3 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAPK3-5350M Recombinant Mouse MAPK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mapk3-3942M Recombinant Mouse Mapk3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAPK3-3574R Recombinant Rat MAPK3 Protein Mammalian Cell His
Rat MAPK3-3230R Recombinant Rat MAPK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAPK3-3230R-B Recombinant Rat MAPK3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAPK3-11551Z Recombinant Zebrafish MAPK3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK3 Related Articles
  • MAPK3 Related Research Area
  • MAPK3 Related Signal Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayIL1R1;IL1A;CACNA1H;MAP4K1;FGFR4;FGF19;MAP2K5;TP53;ATF4
ErbB signaling pathwayRPS6KB2;PLCG2;GRB2;CDKN1BA;PAK2B;PAK2;SHC1;CAMK2B;RAF1B
Ras signaling pathwayIGF1R;PLA2G6;REL;STK4;FGF9;GNGT1;RASGRF2;FGF11;RIN1
Rap signaling pathwayBRAF;SKAP1;KIT;FGF4;MAGI1;KRAS;MAPK3;VEGFA;HRAS
cGMP-PKG signaling pathwayNFATC1;VDAC2;VDAC1;PLCB2;PPP3CB;AGTR1A;GTF2I;INSR;MEF2D
cAMP signaling pathwayCNGA1;GRIN3A;PTGER2;VAV1;AMH;CALML3;CAMK2G;RAC1;PRKACB
Chemokine signaling pathwayPTK2;NFKBIB;WASL;CXCL2;CCL6;RHOA;GNG13;ROCK2;BRAF
HIF- signaling pathwayNOS3;PIK3R2;ENO1;PDK1;PIK3R5;IFNG;FLT1;ERBB2;HKDC1
FoxO signaling pathwayTGFB1;CCND2;IRS1;RAF1;MAP2K2A;PLK4;INSB;TGFB2;GADD45BA
Sphingolipid signaling pathwayPLCB1;RELA;ACER1;ROCK2;PPP2R2A;PLCB3;SGPL1;MAP2K2;PPP2R2D
Phospholipase D signaling pathwayPTK2B;PDGFRB;LPAR4;GRM3;MS4A2;KIT;IL-8;CXCR2;SPHK1
Oocyte meiosisCPEB2;YWHAE2;ADCY1A;IGF1RB;PLCZ1;PPP2R5A;CAMK2D2;CCNB1;CALM
mTOR signaling pathwayINSB;PTENA;RPS6KA1;PRKAA1;CAB39L;AKT2;RPS6KB1B;PIK3R3;PIK3R5
PIK-Akt signaling pathwayINSR;PHLPP2;MDM2;ITGA2B;PKN3;GNG2;FLT1;ITGA2;Ifna15
Adrenergic signaling in cardiomyocytesCREB3L3;KCNQ1;PIK3R3;MAPK12A;PRKACG;MYL2B;AGTR2;ATF6B;RAPGEF3
Vascular smooth muscle contractionPLA2G4C;CALCRLA;ADRA1BB;MLCK2;PLA2G4F;PRKCG;MYLK4;PLA2G12B;NPR1
Dorso-ventral axis formationKRAS;PIWIL2;NOTCH4;NOTCH3;ETV6;NOTCH2;SPIRE2;NOTCH1;GRB2B
TGF-beta signaling pathwaySMAD6;TGFBR1A;LTBP1;BAMBI;TGFB3;INHBA;BMP7;SMAD4;ACVR1C
Axon guidanceCOL9A1A;MYL12A;NFATC3;ARHGEF12;ARPC4;NCAN;CDK5R1B;Plxna2;FRS3
VEGF signaling pathwayBADB;SPHK1;MAPKAPK2A;PLCG1;PLCG2;PLA2G4C;RAC2;SRC;PPP3CB
Osteoclast differentiationMAPK3;FCGR1;PPP3CB;AKT1;CYBA;cgr2b;MAPK9;TGFB2;CSF1
Focal adhesionELK1;MLCK2;PDGFC;PTK6;TNK2;COL2A1B;BCL2;ACTB;ITGA7
Adherens junctionTCF7L1A;SSX2IP;FER;SMAD3A;AASS;ACTB;INSRA;WASL;FGFR1
Gap junctionPRKACAB;CDK1;GNAI2B;RAF1A;PDGFRA;TJP1;PLCB2;PDGFAB;TUBA3B
Signaling pathways regulating pluripotency of stem cellsESRRB;NRAS;ACVR2A;INHBA;SMAD4;AKT1;WNT10B;PCGF1;MAPK12
Platelet activationAKT1;PIK3CG;LCP2;GP1BB;ARHGAP35;GNAI2;MYL12B;PIK3CA;FCER1G
Toll-like receptor signaling pathwayIFNA16;PIK3CA;CCL4;TICAM2;NFKBIA;MAP2K2;MAPK11;IFNA8;IL1B
NOD-like receptor signaling pathwayNLRC4;NFKBIA;IL6;IL18;NLRP3;CARD8;PSTPIP1A;NFKBIAB;CASP5
Natural killer cell mediated cytotoxicityHLA-G;Raet1c;FCGR3A;CD247;PIK3CG;PIK3R3;PIK3R2;PPP3CC;KLRC3
T cell receptor signaling pathwayPLCG1;AKT1;AKT2;VAV2;PRKCQ;PAK1;DEF6A;NFKBIE;PAK2
B cell receptor signaling pathwayPDK2;MALT1;BLNK;SYK;LCP2A;LIME1;PIK3R3;CD79A;PPP3CB
Fc epsilon RI signaling pathwayPLA2G4F;AKT1;LAT;IL13;BTK;PIK3R5;MAP2K3;PIK3CB;FCER1G
Fc gamma R-mediated phagocytosisPLD2;PIK3R2;RPS6KB1;WASF3;FCGR2A;ARF6;FCGR1;MAPK1;VAV2
TNF signaling pathwayMAPK10;MMP14;VCAM1;RELA;CREB3L2;RPS6KA5;MAP2K6;BCL3;Ccl12
Circadian entrainmentMAPK1;GNGT1;GNG10;GRIN2D;ITPR1;GNG8;CALML5;RYR3;GNG12
Long-term potentiationRPS6KA3;PPP1CB;PRKCB;CALM3;CAMK2A;RAF1;MAP2K2;ITPR3;PRKACG
Neurotrophin signaling pathwayPSEN2;NTF4;MAPK3;MAP2K1;PRKCD;NFKBIE;ARHGDIG;RAP1A;KIDINS220
Retrograde endocannabinoid signalingSLC17A7;GNAQ;GRIA4;GRIA3;PRKCA;GRIA1;SLC17A6;NAPEPLD;GNAO1
Glutamatergic synapsePLA2G4C;SLC38A2;GRM3;GRIN2D;PRKACA;GRM4;GNG2;GRIN2A;GRM2
Cholinergic synapseAKT2;CHRM2;CHRM5;KCNJ12;CAMK2D;PRKACG;GNG8;KCNJ2;GNB3
Serotonergic synapseGNB1;HTR5A;HTR1F;HRAS;HTR3A;PRKCB;HTR2B;ITPR1;GNG12
Long-term depressionGNAI3;IGF1;GRIA2;GRIA1;PRKCG;BRAF;PLCB4;ARAF;ITPR1
Regulation of actin cytoskeletonPDGFB;RAF1B;FGF11;RAC1B;ITGAL;PDGFAB;FGF16;ARHGAP35;PAK6
Insulin signaling pathwayHK2;GSK3B;NRAS;ACACA;BAD;PRKACG;PRKAA1;PIK3R3;GRB2A
GnRH signaling pathwayGRB2B;CALML3;ITPR1;CALM3B;MAP3K2;GNRH1;CAMK2G;HRASA;MAP2K3
Progesterone-mediated oocyte maturationCDC16;PIK3R5;PRKACAB;HSP90AA1.1;GNAI2;RPS6KA2;MAPK3;PIK3R2;PRKACA
Estrogen signaling pathwayGABBR2;PIK3CG;GNAI2;PRKACA;KCNJ9;MAP2K2;PLCB4;KCNJ3;SHC2
MelanogenesisTCF7L1A;WNT16;CALM2A;POMCA;WNT9A;GNAI1;EDNRB2;CAMK2D;FZD2
Prolactin signaling pathwayRELA;STAT3;INS1;TH;MAP2K1;SHC4;LHCGR;PIK3R3;SHC1
Thyroid hormone signaling pathwayATP1A1;GSK3B;MDM2;PRKACA;ATP1A4;ITGB3;PRKCA;MTOR;NOTCH1
Oxytocin signaling pathwayCAMK2A;CAMKK2;RYR3;PPP1CC;CACNB2;PRKCA;GUCY1B3;CAMK2B;PPP3CB
Type II diabetes mellitusSOCS2;MAPK3;HK1;PRKCD;INSR;PKM;MTOR;PIK3CA;INS1
Aldosterone-regulated sodium reabsorptionPIK3CD;PRKCB;ATP1A1;NEDD4L;ATP1A3;PRKCA;PIK3R5;PIK3R1;FXYD2
Alzheimers diseaseATP2A2;IDE;ATF6;RYR3;NDUFB9;UQCRH;CALM2;TNFRSF1A;ATP5O
Prion diseasesNCAM2;STIP1;C1QA;HSPA1A;PRKACG;Hc;C9;PRNP;C7
AlcoholismGNG13;HIST1H2BJ;PPP1CB;HIST1H2BB;HDAC2;HDAC3;PDYN;MAPK1;H2AFJ
ShigellosisFBXW11;CTTN;ATG5;NFKBIB;RAC1;ABL1;IL-8;CD44;ROCK2
Salmonella infectionKLC1A;MAPK3;RAC1A;KLC1;NOS2A;IFNG1-2;CD14;PFN2L;MAPK8B
PertussisMAPK9;C4BPA;ITGB1;CXCL5;C1S;Il23a;TNF;C4BPB;NFKB1
LeishmaniasisPRKCB;MAPK1;IL4;MAPK11;IL12A;HLA-DRB5;HLA-DRB3;HLA-DQA2;HLA-DMA
Chagas disease (American trypanosomiasis)FOS;GNAO1;PPP2R2A;CD3D;IL10;CXCL8;TLR9;TGFB2;RELA
ToxoplasmosisIRAK1;NFKB1;MAPK3;GNAI1;PIK3R3;IRGM1;IFNG;TGFB2;Toxoplasma Gondii Profilin Family Protein
TuberculosisARHGEF12;IL12B;CAMK2A;IL18;TGFB3;CAP18;ATP6AP1;IL1A;HLA-DQB1
Hepatitis CAKT2;IRF1;PIAS1;PIK3CB;Ifna15;CLDN6;BRAF;TNFRSF1A;IFNA17
Hepatitis BIL-8;STAT2;CCNA1;EP300;PRKCG;CASP9;MAVS;NFKB1;IKBKB
Influenza AIFNA14;TNFRSF10D;HLA-DRB4;IFNGR1;IFNG;IFNA5;MAPK8;MAP2K4;PRSS1
Pathways in cancerDAPK2;CBL;GNG13;PLCB4;HSP90B1;PLEKHG5;RXRB;LAMA4;EGLN3
Viral carcinogenesisHDAC8;LYN;TTC6;C3;UBR4;HDAC4;HIST3H2BB-PS;DNAJA3;HDAC10
Proteoglycans in cancerRPS6KB1;PIK3R3;CD63;PPP1CC;PIK3CD;PPP1R12A;MAPK3;WNT3;PRKACA
Colorectal cancerMSH3;RAF1;TGFB2;ARAF;MAP2K1;CYCS;PIK3CD;BRAF;MLH1
Renal cell carcinomaEGLN2;PIK3CD;RAP1B;FH;TGFB2;TCEB2;RAF1;PTPN11;RAP1A
Pancreatic cancerAKT2;TGFB3;MAPK8;ARHGEF6;BRAF;BRCA2;RAC3;RALB;NFKB1
Endometrial cancerTCF7L2;MAP2K1;PIK3CA;MAPK1;PIK3R3;AXIN1;CCND1;ERBB2;ARAF
GliomaCALM3;SHC3;PIK3CA;PRKCB;PDGFA;SOS1;TRP53;SHC1;CALM4
Prostate cancerFOXO1;RB1;RAF1;NDRG1;PIK3R2;SRD5A2;CREB3L3;NFKB1;AKT2
Thyroid cancerNCOA4;NTRK1;CCDC6;NRAS;RXRA;LEF1;KRAS;PAX8;HRAS
MelanomaPIK3CG;FGF2;PIK3R5;FGF19;MAPK1;FGF8;FGF13;PIK3R3;NRAS
Bladder cancerTRP53;FGFR3;E2F2;MMP2;MAP2K1;MMP1;THBS1;CDKN2A;TYMP
Chronic myeloid leukemiaNFKB1;PTPN11;CBLC;IKBKB;HDAC1;NRAS;MAP2K2;PIK3R5;STAT5B
Acute myeloid leukemiaAKT3;RARA;MAPK3;RUNX1;JUP;IKBKG;RPS6KB1;MAPK1;STAT3
Non-small cell lung cancerRXRA;MAPK3;RXRG;PIK3R5;MAPK1;BRAF;HRAS;PRKCB;PRKCA
Central carbon metabolism in cancerMET;IDH1;MAPK1;LDHA;PDGFRA;PIK3R3;KIT;HKDC1;SLC2A2
Choline metabolism in cancerCHKA;PDGFRA;MAPK3;MAP2K2;RALGDS;PIK3R2;Pdgfa&Pdgfb;PLCG1;PIK3R3

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACTR8;RIOK3;EPHB2B;FLT1;CCT5;TSSK1;DDX53;KATNA1;UBA1
MAP kinase activityMAPK3;MAPK14B;MAPK14;MAPK8B;MAPK1;MAPK13;MAPK14A;NLK;MAPK11
phosphatase bindingDYSFIP1;SLC9A3R1;CRY2;SYTL2;DLG1L;PPP1R21;SMAD3;CHCHD3;PPP1R26
phosphotyrosine bindingMAPK3;FGR;STAP1;PTPN3;GRB2;CBL;SHC1;CBLB;SAMSN1
protein bindingZBP1;USP44;NAP1L1;CCL3;RCOR1;PBXIP1;PPP2R3A;FAM122A;DSCAM
scaffold protein bindingKRT15;NOS3;CACNA1H;GRIN2A;CRIPT;DLG4;SHANK1;SHANK3;SRC

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.

DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is MAPK3 involved in disease development? 04/29/2023

Dysregulation of MAPK3 signaling has been implicated in the pathogenesis of several diseases. Aberrant activation of MAPK3 is associated with cancer development and progression, as it promotes cell proliferation and survival. MAPK3 signaling is also involved in cardiovascular diseases, contributing to vascular remodeling and hypertrophy. In neurodegenerative diseases, dysregulated MAPK3 activity contributes to neuronal dysfunction and apoptosis.

What are the future directions in MAPK3 research? 03/08/2023

Future research in MAPK3 aims to elucidate the intricate signaling network and identify novel regulatory mechanisms. Understanding the crosstalk between MAPK3 and other signaling pathways will be crucial for developing targeted therapies. Additionally, exploring the role of MAPK3 isoforms in different cellular contexts and disease states will provide valuable insights. Furthermore, the development of more specific and potent inhibitors with reduced toxicity profiles is a focus for future therapeutic interventions.

 What is the molecular structure and function of MAPK3 protein? 09/24/2022

MAPK3, also known as ERK1 (Extracellular Signal-Regulated Kinase 1), is a serine/threonine kinase involved in cell signaling pathways. It consists of 379 amino acids and exhibits a conserved catalytic domain. MAPK3 plays a crucial role in regulating cell proliferation, differentiation, and survival by phosphorylating downstream targets such as transcription factors and other kinases.

What are the downstream effectors of MAPK3 signaling? 11/08/2021

MAPK3 signaling exerts its effects through phosphorylation of downstream targets. It phosphorylates various transcription factors, including ELK1 and c-Fos, leading to changes in gene expression. MAPK3 also phosphorylates other kinases, such as p90RSK, which further propagate the signal to regulate cellular processes like cell cycle progression, apoptosis, and differentiation.

What are the current challenges in targeting MAPK3 for therapy? 01/06/2020

One challenge is the potential for off-target effects when targeting MAPK3, as it is involved in multiple signaling pathways. Additionally, resistance to MAPK3 inhibitors can emerge due to compensatory signaling mechanisms and genetic alterations. Another challenge lies in achieving selective inhibition of specific MAPK3 isoforms without affecting other closely related kinases.

How is the activity of MAPK3 regulated? 11/16/2019

The activity of MAPK3 is tightly regulated by various mechanisms. Activation of MAPK3 involves dual phosphorylation of threonine and tyrosine residues by upstream kinases. Conversely, dephosphorylation by phosphatases can inactivate MAPK3. Additionally, scaffolding proteins and interacting partners can modulate its activity by facilitating or inhibiting its phosphorylation or by regulating its subcellular localization.

What therapeutic strategies target MAPK3? 02/20/2019

Inhibition of MAPK3 activity or downstream effectors represents a potential therapeutic approach. Small molecule inhibitors targeting MAPK3 kinase activity, such as U0126 and PD98059, have been developed. Monoclonal antibodies against MAPK3 or its downstream effectors are also being investigated. Combination therapies targeting multiple components of the MAPK3 signaling pathway are being explored to enhance efficacy and overcome resistance.

Customer Reviews (3)

Write a review
Reviews
12/29/2021

    Exemplary precision and unblemished dependability render it my most cherished research ally.

    01/20/2021

      Presenting exceptional reliability and stability, the experimental reagent establishes a robust foundation for my experiments.

      11/14/2019

        Exquisitely crafted packaging design adds convenience to the usage of this protein reagent and exudes a sense of sophistication.

        Ask a Question for All MAPK3 Products

        Required fields are marked with *

        My Review for All MAPK3 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends