MAPKAPK5
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Official Full Name
mitogen-activated protein kinase-activated protein kinase 5
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Overview
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. -
Synonyms
MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; PRAK; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; MK5; MK-5; MAPKAP-K5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- S.frugiperda
- Sf21
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPKAPK5 Related Articles
MAPKAPK5 involved in several pathways and played different roles in them. We selected most pathways MAPKAPK5 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPKAPK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | MAPK13;IL1R2;MAP2K1;FGF21;PPM1B;RPS6KA1;RPS6KA2;GNA12;TRAF2 |
MAPKAPK5 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, calcium-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPKAPK5 itself. We selected most functions MAPKAPK5 had, and list some proteins which have the same functions with MAPKAPK5. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | NUBPL;CSNK1G2A;TSSK3;SIK3;ATP2B3B;EPHA10;AURKA;ORC4;STYK1 |
MAP kinase kinase activity | PAK3;MAP3K20;MAP3K14;MAP2K7;LRRK2;MAP2K2B;MAP2K6;MAPK14;MAPKAPK5 |
calcium-dependent protein serine/threonine kinase activity | MAPKAPK2B;DCX;CAMK1GA;MAPKAPK5;MKNK1;CAMK1GB;MKNK2B;MKNK2A;MAPKAPK2 |
calmodulin binding | PNCK;NOS3;CAMK1G;MYO1A;C2orf62;USP6;CAMK1;CAMKK1;CAMK2B1 |
calmodulin-dependent protein kinase activity | CAMK2A;MKNK1;DCX;MAPKAPK2B;MKNK2B;CAMK4;CAMK2B1;CAMK2G;MAPKAPK5 |
mitogen-activated protein kinase binding | PTPRJ;TPR;MAPKAPK5;SIRT1;MAPKAPK2B;GTF2I;MAPKAPK2A;ARRB2;MAPK7 |
p53 binding | HTT;GATA1;DAXX;ZNF346;NUAK1;ZFP385C;BANP;EP300;RNF34 |
protein binding | MED8;ACY1;LYL1;KRTAP9-2;SPTBN1;FBXW9;ST13;CRY2;ABL1 |
protein serine/threonine kinase activity | MAP3K9;MAP2K7;STRC;CAMK1DA;PBK;BMPR1AA;MLKL;CDK11A;MAP4K4 |
signal transducer activity | AXIN1;PTK2;OLFR477;GPR15;CXCR4A;C18orf32;TAS2R202;GPR158;LPAR6A |
MAPKAPK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPKAPK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPKAPK5.
MAPK6; saicar; TP53; HSPB1; PKM; SRPK2; SRPK1; MAPK1; MAPK9; EIF4EBP1; RPL13; TAB1; MAPK14
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