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MARCH9

Official Full Name

membrane-associated ring finger (C3HC4) 9
Overview

MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).
Synonyms

MARCH9; membrane-associated ring finger (C3HC4) 9; E3 ubiquitin-protein ligase MARCH9; FLJ36578; RNF179; FLJ36578; BC019560; E3 ubiquitin protein ligase MARCH9; MARCH IX; Membrane associated RING CH protein IX; membrane associated ring finger (C3HC4) 9; Membrane associated RING finger protein 9; RING finger protein 179; RNF179; OTTHUMP00000243862; RING finger protein 179; membrane-associated RING-CH protein IX; membrane-associated RING finger protein 9; MARCH-IX;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Mouse
Mus musculus (Mouse)
Rhesus Macaque

Source

E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	MARCH9-9562M	Recombinant Mouse MARCH9 Protein	Mammalian Cell	His		Inquiry
Mouse	MARCH9-5369M	Recombinant Mouse MARCH9 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MARCH9-5369M-B	Recombinant Mouse MARCH9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL18741HF	Recombinant Full Length Human E3 Ubiquitin-Protein Ligase March9(41342) Protein, His-Tagged	E.coli expression system	His	Full Length (1-346)	Inquiry
Mus musculus (Mouse)	RFL23180MF	Recombinant Full Length Mouse E3 Ubiquitin-Protein Ligase March9(41342) Protein, His-Tagged	E.coli expression system	His	Full Length (1-348)	Inquiry
Rhesus Macaque	MARCH9-2682R	Recombinant Rhesus monkey MARCH9 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MARCH9-2502R	Recombinant Rhesus Macaque MARCH9 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MARCH9-2502R-B	Recombinant Rhesus Macaque MARCH9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

MARCH9 involved in several pathways and played different roles in them. We selected most pathways MARCH9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MARCH9 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH9 itself. We selected most functions MARCH9 had, and list some proteins which have the same functions with MARCH9. You can find most of the proteins on our site.

Function	Related Protein
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	MARCH11;MYLIPA;RAG1;ITCHA;NEURL1B;RC3H2;MYLIPB;MARCH6;RNF187
coenzyme F420-0 gamma-glutamyl ligase activity	RNF169;MARCH4;NEURL3;ARIH1L;G2E3;MYLIPA;RNF144AA;RNF149;RFWD2
coenzyme F420-2 alpha-glutamyl ligase activity	TRIM50;ZNRF2B;MGRN1A;MYLIPA;RAG1;ITCHA;RNF144AB;ARIH1L;NEURL3
ligase activity	UNKL;RNF212;TRIM33;UBE1Y1;GLULA;TRAIP;BIRC3;ADSSL;TRIML1
metal ion binding	TNNI3K;CD209A;TRERF1;KAT6A;PLCD3;ZCCHC16;ZFP503;MARCH6;PPM1G
molecular_function	LRIT1;OTULINA;ZFP474;SLC35F3A;TMEM57B;SINUP;SNCGB;IGDCC4;SCOCB
protein-glutamic acid ligase activity	SIAH1A;HECW2;MARCH9;RC3H2;SIAH2L;RNF149;TRIM71;DTX1;UBE2IB
protein-glycine ligase activity	SIAH1A;RNF144AB;TMEM129;DTX1;TRIM71;UBE2IA;NEURL3;HERC2;MGRN1A
protein-glycine ligase activity, elongating	ARIH1L;RC3H2;ZNRF2B;MYLIPB;RNF144AA;ZNRF3;HERC2;UBE2IA;MYLIPA
protein-glycine ligase activity, initiating	ZNRF2B;UBE2IB;HERC2;RNF144AB;ITCHA;TRIM71;RFWD2;RAG1;ARIH1L
ribosomal S6-glutamic acid ligase activity	ITCHA;RNF180;MUL1A;RNF149;HERC2;MARCH11;MARCH5L;NEURL3;LTN1
tubulin-glutamic acid ligase activity	SIAH1A;RAG1;MGRN1A;RFWD2;TRIM71;ITCHA;TRIM41;TRIM50;NEURL3
tubulin-glycine ligase activity	HECW2;MARCH9;HERC2;RNF144AA;MYLIPB;LTN1;SIAH2L;FLR;NEURL3
zinc ion binding	NR1H3;SETDB1B;RNF19B;RXRGA;RNF121;CA15C;UNK;KDM2B;ZDHHC11

MARCH9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH9.