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MASP2

  • Official Full Name

    mannan-binding lectin serine peptidase 2

  • Overview

    The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.
  • Synonyms

    MASP2; mannan-binding lectin serine peptidase 2; mannan binding lectin serine peptidase 1 pseudogene 1 , mannan binding lectin serine protease 1 pseudogene 1 , mannan binding lectin serine protease 2 , MASP1P1; mannan-binding lectin serine protease 2; Mannan binding lectin serine peptidase 2; Mannan binding lectin serine protease 2; Mannose binding protein associated serine protease 2; MAP 19; MAP19; MASP 2; MBL associated plasma protein of 19 kD; MBL associated serine protease 2; Small MBL associated protein; sMAP; small MBL-associated protein; MBL-associated serine protease 2; MBL-associated plasma protein of 19 kD; mannan-binding lectin serine protease 1 pseudogene 1; mannose-binding protein-associated serine protease 2; mannan-binding lectin serine peptidase 1 pseudogene 1; MASP-2; MASP1P1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MASP2-45H Recombinant Human MASP2 protein, GST-tagged Wheat Germ GST
Human MASP2-903H Recombinant Human MASP2 protein, His-tagged E.coli His Gly170~Thr287
Human MASP2-906H Recombinant Human MASP2 protein, His-tagged E.coli His Trp22~Cys142
Human MASP2-904H Recombinant Human MASP2 protein, His-tagged E.coli His Thr280~Val433
Human MASP2-46H Recombinant Human MASP2 protein, His-tagged E.coli His
Human MASP2-905H Recombinant Human MASP2 protein, His-tagged E.coli His Ile445~Ile683
Human MASP2-4458HCL Recombinant Human MASP2 293 Cell Lysate HEK293 N/A
Human MASP2-4459HCL Recombinant Human MASP2 293 Cell Lysate HEK293 N/A
Human MASP2-3927H Recombinant Human MASP2 Protein (Thr287-Phe686), N-His tagged E.coli N-His Thr287-Phe686
Human MASP2-1451H Recombinant Human MASP2 protein, His-tagged Insect Cell His 16-686aa
Human MASP2-630HF Recombinant Full Length Human MASP2 Protein, GST-tagged In Vitro Cell Free System GST 686 amino acids
Mouse MASP2-9577M Recombinant Mouse MASP2 Protein Mammalian Cell His
Mouse MASP2-5380M Recombinant Mouse MASP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MASP2-2171M Recombinant Mouse MASP2 Protein (20-685 aa), His-tagged E.coli His 20-685 aa
Mouse MASP2-5380M-B Recombinant Mouse MASP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse MASP2-2795M Recombinant Mouse MASP2 Protein (20-685 aa), His-tagged Insect Cell His 20-685 aa
Rat Masp2-1446R Recombinant Rat Masp2 protein, His-tagged Insect Cell His 20-685aa
Zebrafish MASP2-6605Z Recombinant Zebrafish MASP2 Mammalian Cell His
Chicken MASP2-7140C Recombinant Chicken MASP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MASP2 Related Articles

MASP2 involved in several pathways and played different roles in them. We selected most pathways MASP2 participated on our site, such as Complement and Coagulation Cascades, Complement cascade, Creation of C4 and C2 activators, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and Coagulation CascadesF2;F9;F2R;MASP2;F5;C1RA;Serpina1c;SERPINF2;CPB2
Complement cascadeCFHL4;IGKC;CFD;IGKV1-5;FCN1;CR1;IGLC2;BFB;HBL3
Creation of C4 and C2 activatorsIgG3;IGKC;IGLC2;IGKV1-5;FCN2;CRP;HBL3;C1rb;MASP2
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceMASP2;FCN2;FCN3;FCN1
Immune SystemUBA5;STUB1;RAET1E;WWP1;CFHL4;NLRC5;CTSO;BAIAP2;CLEC2G
Initial triggering of complementIgG3;BFB;C1rb;CRP;CFD;FCN2;FCN1;MASP2;GZMM
Innate Immune SystemMAP3K8;RIPK3;CTSLL;DEFB106A;CLEC4A;WIPF2;CASP4;NCKIPSD;MASP2

MASP2 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, complement component C4b binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MASP2 itself. We selected most functions MASP2 had, and list some proteins which have the same functions with MASP2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingSCGN;BMP1B;F7I;PCDHB13;RAB11FIP4A;MICU2;F9B;SYT15;PCDH2G16
calcium-dependent protein bindingSNAP25;CALM3;VAMP2;ANXA7;S100A11;STMN2;ANXA3;KOP;ALG2
complement component C4b bindingCR1;MASP2
peptidase activityNAPSA;CAPN1B;PRSS44;TMPRSS5;CTSLL;USPL1;METAP2B;PAPPAB;ST14A
protein bindingNR3C1;CNIH4;ZBP1;CCL5;NOS2;ACTG1;ICAM1;ASAP1;MLLT4
serine-type endopeptidase activityHGFA;PLAT;KLK14;MASP1;C1RA;PRSS38;PRSS22;KEX2;F2

MASP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MASP2.

Dlg4

Bongoni, AK; Kiermeir, D; et al. Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models. TRANSPLANTATION 96:791-799(2013).
Degn, SE; Thiel, S; et al. MAp19, the alternative splice product of the MASP2 gene. JOURNAL OF IMMUNOLOGICAL METHODS 373:89-101(2011).
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