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MASTL

Official Full Name

microtubule associated serine/threonine kinase-like
Overview

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.
Synonyms

MASTL; microtubule associated serine/threonine kinase-like; serine/threonine-protein kinase greatwall; FLJ14813; THC2; 2700091H24Rik; C88295; GW; GWL; GWL_HUMAN; hGWL; MAST-L; MGC117975; microtubule associated serine/threonine kinase like; Microtubule-associated serine/threonine-protein kinase-like; RP11 85G18.2; greatwall protein kinase; GREATWALL; RP11-85G18.2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Insect Cell
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MASTL-156H	Active Recombinant Human MASTL Protein, GST-tagged	Insect Cell	GST		Inquiry
Human	MASTL-757H	Recombinant Human MASTL, His-tagged	E.coli	His	34-219aa	$319 / 25ug
Human	MASTL-4456HCL	Recombinant Human MASTL 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	MASTL-9582M	Recombinant Mouse MASTL Protein	Mammalian Cell	His		Inquiry
Mouse	Mastl-3968M	Recombinant Mouse Mastl Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	MASTL-5382M	Recombinant Mouse MASTL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MASTL-5382M-B	Recombinant Mouse MASTL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MASTL-1035Z	Recombinant Zebrafish MASTL	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MASTL Related Articles

MASTL involved in several pathways and played different roles in them. We selected most pathways MASTL participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	SKA1;CENPO;CCND3;NUF2;MSH5;SMC1A;CCNH;SETA;TCTN2
Cell Cycle, Mitotic	ZWILCH;MYBL2;RBBP4;SGOL2;CTDNEP1;DPF1;OFD1;NCAPH2;INCENP
M Phase	CENPH;NDC80;ERCC6L;GORASP1;RCC2;CTDNEP1A;SPC25;TMPO;ARPP19
MASTL Facilitates Mitotic Progression	ARPP19A;ENSA;ARPP19B;ENSAA;ENSAB;ARPP19;MASTL
Mitotic Prophase	SETA;GORASP2;PHF8;CTDNEP1;ENSAB;SMC2;CNEP1R1;ENSA;ENSAA

MASTL has several biochemical functions, for example, ATP binding, kinase activity, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MASTL itself. We selected most functions MASTL had, and list some proteins which have the same functions with MASTL. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DDR2;LMTK3;PTK2BB;LIG4;TOR1L1;CCT2;IKBKAP;CLCN4-2;ITPKB
kinase activity	PRPS2;CAMK2A;DNAJC3B;NTRK2B;MAP2K4A;GRK1B;BSK146;UCK2A;CKBA
protein phosphatase 2A binding	RPS6KB1;MAPT;PPP2R4;SMG7;ARPP19;CTTNBP2NL;PPP2R2A;ANKLE2;GRIN3A
protein serine/threonine kinase activity	SPEG;MAP2K4;PRKCE;CAMK1GB;MAP2K1;NEK7;RPS6KA1;TLK1B;RPS6KA3A

MASTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASTL here. Most of them are supplied by our site. Hope this information will be useful for your research of MASTL.

Dynll1; MED26; SSFA2; TAP2; CDK18; RPS6KA1; SLC1A5; MRPL2; ACBD5; CEP85; FASTKD5; TMEM263; PLEKHA8; DERL2; EPB41L5; UBN1; TELO2

Wang, L; Fisher, LA; et al. Monoclonal Antibodies Against Xenopus Greatwall Kinase. HYBRIDOMA 30:469-474(2011).