MAT2A
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Official Full Name
methionine adenosyltransferase II, alpha
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Overview
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. -
Synonyms
MAT2A; methionine adenosyltransferase II, alpha; S-adenosylmethionine synthase isoform type-2; MATA2; MATII; SAMS2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2;
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What is mat2a protein?
MAT2A protein, also known as methionine adenosyltransferase 2 alpha, is an enzyme involved in the biosynthesis of S-adenosylmethionine (SAM), which is an important co-factor in various biochemical reactions. SAM is a primary methyl donor and is involved in DNA and protein methylation, as well as in the synthesis of various molecules including neurotransmitters, hormones, and phospholipids.
MAT2A catalyzes the conversion of methionine and ATP to SAM, utilizing adenosine triphosphate (ATP) as a phosphate donor. This reaction is crucial for maintaining intracellular levels of SAM, which is required for methylation reactions and other cellular processes.
What is the function of mat2a protein?
The enzyme MAT2A and its function in SAM synthesis are vital for regulating various physiological processes in the body, including liver metabolism, cellular growth and differentiation, and neurotransmitter metabolism. Dysregulation of MAT2A can contribute to liver diseases, such as hepatocellular carcinoma and liver fibrosis, as well as other conditions like cancer, neurological disorders, and metabolic disorders.
Mat2a related signaling pathway
In terms of biomedical applications, targeting MAT2A or its associated pathways may have potential therapeutic benefits. Developing small molecules or inhibitors that specifically target MAT2A activity could potentially be used for the treatment of diseases associated with abnormal SAM metabolism, particularly those involving aberrant DNA methylation patterns. However, further research is needed to fully understand the complex role of MAT2A and its potential applications in the field of biomedicine.
Mat2a Related Diseases
- Liver diseases: Dysregulation of Mat2a can contribute to liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer.
- Cardiovascular diseases: Altered Mat2a expression or activity has been implicated in cardiovascular diseases including atherosclerosis and hypertension.
- Cancer: Mat2a is involved in regulating methionine metabolism, which plays a critical role in cancer cell growth and proliferation. Dysregulation of Mat2a can contribute to the development and progression of various types of cancer.
- Biomarker for disease diagnosis: Mat2a expression levels or activity can serve as potential biomarkers for the diagnosis and prognosis of certain diseases, including liver diseases and cancer.
- Drug discovery: Understanding the structure and function of Mat2a can aid in the development of drugs that can selectively modulate its activity. This can help in developing novel therapeutic agents for various diseases. Overall, further research on the function and regulation of Mat2a can provide additional insights into its potential biomedical applications.
Biomedical Application of mat2a Protein
- Biomarker for disease diagnosis: Mat2a expression levels or activity can serve as potential biomarkers for the diagnosis and prognosis of certain diseases, including liver diseases and cancer.
- Drug target: As Mat2a plays a role in various diseases, it can be targeted for therapeutic interventions. Modulating Mat2a activity or expression can be a potential strategy for treating diseases such as liver diseases and cancer.
- Drug discovery: Understanding the structure and function of Mat2a can aid in the development of drugs that can selectively modulate its activity. This can help in developing novel therapeutic agents for various diseases. Overall, further research on the function and regulation of Mat2a can provide additional insights into its potential biomedical applications.
High Purity
Fig1. SDS-PAGE (MAT2A-1517H)
(Qun Li, 2023)
Fig2. Epigenetic inhibitors mediated upregulation of intracellular SAM levels. Relative expression of MAT1A mRNA for cells in (A) using GAPDH as a reference.
(Dong-chuan Guo, 2015)
Fig3. Zebrafish were phenotyped with light microscopy 72 dpf after mat2aa MO injection in the zebrafish Tg(flk1:EGFP.) Representative images are shown. Zebrafish mat2aa MO injection resulted in significant defects on embryonic development. Co-injection of wild-type (WT) MAT2A mRNA, in comparison with the substitution mRNA, significantly reduced defects of cardiovascular development.
(Menghui Xu , 2022)
Fig4. Zebrafish were phenotyped with light microscopy 72 dpf after mat2aa MO injection in the zebrafish Tg(flk1:EGFP.) Representative images are shown. Zebrafish mat2aa MO injection resulted in significant defects on.
MAT2A involved in several pathways and played different roles in them. We selected most pathways MAT2A participated on our site, such as Cysteine and methionine metabolism, Metabolic pathways, Biosynthesis of amino acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAT2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | MDH1;AGXT2;CBSA;DNMT3AB;LDHC;CBS;BHMT;MAT2AB;GOT2A |
| Metabolic pathways | IMPAD1;GCNT2;HADH;GALNTL6;PKMB;DPM3;COX5AA;CYP2U1;PRPS1 |
| Biosynthesis of amino acids | ENO1;PRPS1;ENO2;TKT;PGAM1B;RPE;MAT2AL;GPT;RPIA |
MAT2A has several biochemical functions, for example, ATP binding, metal ion binding, methionine adenosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAT2A itself. We selected most functions MAT2A had, and list some proteins which have the same functions with MAT2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTA2;MST1R;DCKL1B;PRKACBA;TSSK5;NME1;MOV10;RPS6KC1;SNRKA |
| metal ion binding | RPL37A;SKINT8;ZNF567;HIC2;NME6;COL27A1;TMPPE;LRP2;PPM1LA |
| methionine adenosyltransferase activity | MAT2AA;MAT2AL;MAT2AB;MAT2A;MAT1A |
| protein binding | MAP3K2;EGLN2;ADRA2A;METTL21C;PCP4;KRT7;RALYL;FCN3;TRMT112 |
MAT2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAT2A here. Most of them are supplied by our site. Hope this information will be useful for your research of MAT2A.
MAT2B; SAP18; ARF6; IKBKE; ACTR6; PRKAB1; TRAF6; y1062; yscT; thyA; q5nh68_fratt; nadM; rpoB; q7chb5_yerpe
- Q&As
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Q&As (5)
Ask a questionYes, dysregulation of MAT2A expression has been associated with certain cancers. Understanding its role in cancer metabolism could lead to targeted therapies.
In theory, inhibiting MAT2A could alter cellular methylation patterns, making it a potential strategy for disorders characterized by abnormal methylation.
MAT2A influences cellular methylation patterns by providing SAMe, a methyl donor essential for the methylation of proteins, lipids, and nucleic acids.
SAMe, produced by MAT2A, is a precursor for neurotransmitter synthesis. Altered MAT2A function may have implications for neurological disorders like depression and schizophrenia.
MAT2A-derived SAMe is essential for DNA methylation. Aberrant DNA methylation is a hallmark of cancer, and targeting MAT2A may have implications for epigenetic cancer therapies.
Customer Reviews (3)
Write a reviewIts exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.
Incorporating the ARRB2A protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.
Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.
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