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Mbl1

Official Full Name

mannose-binding lectin (protein A) 1
Overview

MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa andfungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system.Another important function of MBL is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.
Synonyms

MBL1; mannose-binding lectin (protein A) 1; mannose-binding protein A; mannose binding lectin (A); MBP A; S MBP; raRF p28B; mannan-binding protein; mannose binding lectin, serum (A); ra-reactive factor polysaccharide-binding component p28B; MBL-A; MBP-A; S-MBP;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Mouse
Rat

Source

Baculovirus-Insect cells
HEK293
Human Cell
Mammalian Cell

Tag

C
hFc
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	Mbl1-803M	Recombinant Mouse Mbl1, His tagged	Human Cell	His		$623 / 50 µg
Mouse	MBL1-2776MCL	Recombinant Mouse MBL1 cell lysate	Human Cell	N/A		Inquiry
Mouse	Mbl1-0145M	Recombinant Mouse Mbl1 Protein (Ser18-Ala239), C-His-tagged	Baculovirus-Insect cells	C-His	Ser18-Ala239	Inquiry
Rat	Mbl1-20R	Recombinant Rat Mbl1, Fc tagged	Human Cell	His		Inquiry
Rat	MBL1-3602R	Recombinant Rat MBL1 Protein	Mammalian Cell	His		Inquiry
Rat	MBL1-1113RCL	Recombinant Rat MBL1 cell lysate	Human Cell	N/A		Inquiry
Rat	MBL1-3258R	Recombinant Rat MBL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MBL1-1286R	Recombinant Rat MBL1 protein(Met1-Ala238), hFc-tagged	HEK293	C-hFc	Met1-Ala238	Inquiry
Rat	MBL1-3258R-B	Recombinant Rat MBL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Mbl1 Related Research Area

Mbl1 involved in several pathways and played different roles in them. We selected most pathways Mbl1 participated on our site, such as Phagosome, Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mbl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	FCGR3;ATP6AP1;RAC1;CD209A;CANX;BLB2;DYNC1LI1;CD209B;ATP6V1C1
Complement and coagulation cascades	SERPINE1;GM5077;Serpina1b;F10;PLAU;PLAUR;Serpina1c;A2M;SERPIND1
Staphylococcus aureus infection	C4A;HLA-DRB5;PTAFR;FGG;C1QC;ITGAM;SELP;FCGR3A;FCAR

Mbl1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mbl1 itself. We selected most functions Mbl1 had, and list some proteins which have the same functions with Mbl1. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	ANXA1;NOTCH1;EFCAB3;CASQ1;CLGN;PCDH2G29;PLA2G4A;EHD1A;EHD1B
calcium-dependent protein binding	NRXN1;ANXA6;CASQ2;MMP13;MBL1;TNNC1;VLDLR;CPNE3;PDCD6IP
carbohydrate binding	CHODL;GFPT1;OLR1;KLRB1B;GALNT3;MAN2C1;CLEC7A;PYGB;ASGR2
mannose binding	IGF2R;BSG;DPM1;CLN5;Acr;LMAN2;CD209C;CD209;LMAN1
phosphatidylinositol-4-phosphate binding	OSBPL8;OSBPL5;SNX24;GOLPH3L;SH3PXD2B;SESTD1;SNX3;RS1;PRRC2B
polysaccharide binding	CLEC4G;PRG4A;CLEC18A;VTN;ENPP2;ENPP1;PRG4;CLEC18C;PRG4B
protease binding	SERPINF2;TIMP4;PEO1;COMP;SERPINC1;Serpina1b;SERPINB9;SERPINA1;BDKRB2
protein homodimerization activity	SNX2;BAXB;PYCARD;PDCD6;APOA1BP;FGFR2;EEA1;RQCD1;SLC9A7

Mbl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mbl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mbl1.

Acute Phase Proteins