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MC3R

  • Official Full Name

    melanocortin 3 receptor

  • Overview

    This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
  • Synonyms

    MC3R; melanocortin 3 receptor; MC3; OB20; OQTL; BMIQ9; MC3-R; melanocortin receptor 3; obesity quantitative trait locus;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MC3R-772H Recombinant Human MC3R, GST-tagged E.coli GST 1-90aa
Human MC3R-1769H Recombinant Human MC3R Protein, His&GST-tagged E.coli N-His&GST Met1-Asp117
Mouse MC3R-9616M Recombinant Mouse MC3R Protein Mammalian Cell His
Mouse MC3R-5401M-B Recombinant Mouse MC3R Protein Pre-coupled Magnetic Beads HEK293
Mouse MC3R-5401M Recombinant Mouse MC3R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MC3R-3609R Recombinant Rat MC3R Protein Mammalian Cell His
Rat MC3R-3265R Recombinant Rat MC3R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MC3R-3265R-B Recombinant Rat MC3R Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL2121HF Recombinant Full Length Human Melanocortin Receptor 3(Mc3R) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Mus musculus (Mouse) RFL17626MF Recombinant Full Length Mouse Melanocortin Receptor 3(Mc3R) Protein, His-Tagged E.coli expression system His Full Length (1-323)
Rattus norvegicus (Rat) RFL7811RF Recombinant Full Length Rat Melanocortin Receptor 3(Mc3R) Protein, His-Tagged E.coli expression system His Full Length (1-323)
Zebrafish MC3R-9614Z Recombinant Zebrafish MC3R Mammalian Cell His
Kit-1032 Total Polyamine Assay Kit (Fluorometric) N/A
Kit-1372 MC3R Total GPCR Internalization Assay Kit N/A
Kit-1373 cAMP MC3R CHO-K1 GPCR Assay Kit N/A
Kit-1374 MC3R U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MC3R Related Articles

MC3R involved in several pathways and played different roles in them. We selected most pathways MC3R participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC3R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGRIN2B;TAAR12I;GRIN2C;TAAR14D;LEPA;GABRA2;GRIN2D;EDNRBA;P2RY8

MC3R has several biochemical functions, for example, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MC3R itself. We selected most functions MC3R had, and list some proteins which have the same functions with MC3R. You can find most of the proteins on our site.

Function Related Protein
melanocortin receptor activityMC1R;MC2R;MC5RB;MC5R;MC3R;MC5RA;MC4R
melanocyte-stimulating hormone receptor activityMC4R;MC3R;MC1R
neuropeptide bindingMC4R;SSTR2;GPR149;SSTR4;NPBWR1;NPY8AR;OPRD1;MRGPRX2;SSTR5
peptide hormone bindingACVR1;AGTR1A;MC4R;ECE1;MC3R;GCGR;GALR2;HCRTR1;AGTR1B
protein bindingSTMN1;EFHC1;GPA33;GDF5;DLGAP4;CEP72;VARS;TTC23L;RAB11FIP5

MC3R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC3R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC3R.

MRAP; MRAP2

Peter, JC; Zipfel, G; et al. Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 30:444-453(2010).
Getting, SJ; Lam, CW; et al. [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). MOLECULAR PHARMACOLOGY 70:1850-1855(2006).
  • Q&As
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