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MCCC1

Official Full Name

methylcrotonoyl-CoA carboxylase 1 (alpha)
Overview

This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.
Synonyms

MCCC1; methylcrotonoyl-CoA carboxylase 1 (alpha); methylcrotonoyl Coenzyme A carboxylase 1 (alpha); methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCA; 3-methylcrotonyl-CoA carboxylase 1; MCCase subunit alpha; OTTHUMP00000212827; OTTHUMP00000212828; OTTHUMP00000212829; OTTHUMP00000212832; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha); 3-methylcroto; MCC-B;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCCC1-401H	Recombinant Human MCCC1 Protein, His-tagged	E.coli	His		Inquiry
Human	MCCC1-4429HCL	Recombinant Human MCCC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MCCC1-2429H	Recombinant Human MCCC1 Protein, His-tagged	E.coli	N-His	Ala512-Glu725	Inquiry
Mouse	MCCC1-9624M	Recombinant Mouse MCCC1 Protein	Mammalian Cell	His		Inquiry
Mouse	Mccc1-8173M	Recombinant Mouse Mccc1 protein, His & T7-tagged	E.coli	His/T7	Phe484~Lys717 (Accession # Q99MR8)	Inquiry
Mouse	MCCC1-5405M	Recombinant Mouse MCCC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MCCC1-5405M-B	Recombinant Mouse MCCC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MCCC1-3614R	Recombinant Rat MCCC1 Protein	Mammalian Cell	His		Inquiry
Rat	MCCC1-3270R	Recombinant Rat MCCC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MCCC1-3270R-B	Recombinant Rat MCCC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MCCC1-4019Z	Recombinant Zebrafish MCCC1	Mammalian Cell	His		Inquiry
Chicken	MCCC1-1689C	Recombinant Chicken MCCC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MCCC1 involved in several pathways and played different roles in them. We selected most pathways MCCC1 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Valine, leucine and isoleucine degradation	ALDH9A1A.1;AOX3;ACAA2;HIBADHB;OXCT2A;OXCT1A;HIBCH;HMGCS1;ALDH3A2
Metabolic pathways	ACMSD;TYR;PLA2G2F;PANK1B;KLF15;CYP2P7;SUCLG2;MGAT3A;PFAS

MCCC1 has several biochemical functions, for example, ATP binding, biotin binding, biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC1 itself. We selected most functions MCCC1 had, and list some proteins which have the same functions with MCCC1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DCLK2;OASL2;PFKFB2;NEK3;NLK2;ERCC6L2;PIK3CA;PIP4K2A;DDX50
biotin binding	HLCS;PCXB;PC;PCCA;PCXA;MCCC1;AVR2
biotin carboxylase activity	MCCC1;PCXB;ACACA;PC;PCCA;ACACB;PCXA
metal ion binding	SP8;BMP1B;ADPRM;CYP2AD3;FAM170A;ATP1A1A.2;SALL3;KDM7AB;CHPT1
methylcrotonoyl-CoA carboxylase activity	MCCC2;MCCC1
protein binding	LILRB4;CDK2;SPATC1;KLK6;ATP6V1E2;LIMS1;ADRB3;RAB1;SH2D3A

MCCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC1.

US11; IFIT1; PPP2R2B; STK4; SIRT4