MDH2
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Official Full Name
malate dehydrogenase 2, NAD (mitochondrial)
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Overview
Malate dehydrogenase (MDH) is a key enzyme in the tricarboxylic acid cycle and malate/aspartate shuttle. MDH is widely expressed in organisms from most bacteria to all eukaryotes. The cytoplasmic MDH isoenzyme (cMDH or MDH1) primarily reduces oxaloacetate -
Synonyms
MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; MOR1; M-MDH; MGC:3559;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MDH2 involved in several pathways and played different roles in them. We selected most pathways MDH2 participated on our site, such as Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | IDH3G;DLDH;DLD;IDH1;OGDHA;SDHB;ACO2;ACO1;IDH3B |
| Cysteine and methionine metabolism | DNMT3AB;DNMT3AA;DNMT3;MDH1AA;GOT2;CDO1;MDH1;MPST;CBSA |
| Pyruvate metabolism | LDHB;HAGHL;ALDH7A1;ALDH9A1A.1;LDHAL6B;GRHPR;LDHA;GRHPRB;PDHA1B |
| Glyoxylate and dicarboxylate metabolism | MDH2;AGXTB;PCCB;GLYCTK;ACO2;GCSH;MCEE;HYI;HAO1 |
| Metabolic pathways | PNP5A;MBOAT1;ADH2-1;UMPS;NME2B.2;CBR1L;FUT2;CYP4A10;ALDOAA |
| Carbon metabolism | IDH3B;IDH2;SDS;ALDH6A1;ESD;PGAM2;AGXTB;PDHA1A;HADHAB |
MDH2 has several biochemical functions, for example, L-malate dehydrogenase activity, malate dehydrogenase (NADP+) activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDH2 itself. We selected most functions MDH2 had, and list some proteins which have the same functions with MDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-malate dehydrogenase activity | MDH1AA;MDH1;MDH2 |
| malate dehydrogenase (NADP+) activity | |
| poly(A) RNA binding | ALG13;SARS2;NOP2;CCDC124;PPP1R2P9;METTL16;MTERF;RALYL;CDK11B |
| protein self-association | SHANK3;AGXT;NKX3;EPB49;SLC9A3R1;PABPN1;TRIM32;TMEM190;AGTR1B |
MDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH2.
VCAM1; PCNA; FHIT; WARS; ere_dna; MAPK13; GABARAP; FN1; NS; ATF2; GABARAPL2; GABARAPL1; MAP1LC3A
- Q&As
- Reviews
Q&As (5)
Ask a questionCurrently, there are no specific drugs targeting MDH2 approved for clinical use, but research is ongoing to explore potential therapeutic interventions.
Emerging research suggests a potential link between MDH2 dysfunction and neurodegenerative diseases, opening avenues for further investigation.
Abnormal MDH2 expression is observed in some cancer types, suggesting its potential role as a diagnostic or therapeutic target in cancer treatment.
MDH2 participates in the citric acid cycle, facilitating the conversion of malate to oxaloacetate and contributing to the production of ATP in the mitochondria.
Yes, altered MDH2 levels can serve as a biomarker for metabolic diseases, aiding in early detection and monitoring of these conditions.
Customer Reviews (3)
Write a reviewIts ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
The use of MDH2 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
The manufacturer of MDH2 protein plays a crucial role in supporting my research endeavors.
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