ME1
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Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolic
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Overview
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. -
Synonyms
ME1; malic enzyme 1, NADP(+)-dependent, cytosolic; NADP-dependent malic enzyme; NADP-ME; malate dehydrogenase; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; pyruvic-malic carboxylase; MES; HUMNDME;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- 6×His
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ME1 Related Articles
ME1 involved in several pathways and played different roles in them. We selected most pathways ME1 participated on our site, such as Pyruvate metabolism, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism | PDHA2;PCK1;FH;PDK2;LDHA;PDHA1;LDHB;PDPR;ACACB |
| Metabolic pathways | PC;NANSA;CYP2J5;PPOX;PIGU;LIPC;udp;SCLY;ACADL |
| Carbon metabolism | ACSS2L;OGDHL;PDHA2;GLUD1A;HAO2;DLAT;ENO1;RPE;ECHS1 |
| PPAR signaling pathway | PPARD;PDPK1B;SLC27A1B;CYP4A10;PLIN1;ANGPTL4;ME1;Scd2;CPT1C |
ME1 has several biochemical functions, for example, ADP binding, NAD binding, NADP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ME1 itself. We selected most functions ME1 had, and list some proteins which have the same functions with ME1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | CYB5R3;APAF1;ME1;ABCG1;HSP104;ADCK3;ACTA1;P2RY1;ATP1A1 |
| NAD binding | HIBADH;GPD1B;UGDH;IDH3A;CTBP2L;DLD;GRHPRB;AOX3L1;GRHPRA |
| NADP binding | POR;HMGCRB;IDH1;GAPDH;NOX5;DPYD;GSR;FMO3;GAPDHS |
| electron carrier activity | ACOX2;FDX1;SDHC;COX5A;HSD17B6;ACADSB;NDUFA12;ACAD11;HAAO |
| malate dehydrogenase (decarboxylating) (NAD+) activity | ME3;ME1;ME2 |
| malate dehydrogenase (decarboxylating) (NADP+) activity | ME3;ME1 |
| malic enzyme activity | ME2;ME1;ME3;MDH1 |
| manganese ion binding | B4GALT7;MRE11A;PPEF1;LARGE;MPPE1;ATP2C1;GYLTL1B;PAPOLA;MTPAP |
| oxaloacetate decarboxylase activity | FAHD1;ME1;ME2;ME3 |
ME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ME1.
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