MECP2
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Official Full Name
methyl CpG binding protein 2 (Rett syndrome)
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Overview
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009] -
Synonyms
MECP2; methyl CpG binding protein 2 (Rett syndrome); RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13; methyl-CpG-binding protein 2; meCp-2 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MECP2 Related Articles
MECP2 involved in several pathways and played different roles in them. We selected most pathways MECP2 participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MECP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | TSPYL1;POU2F2;LMX1B;KCNJ8;DEAF1;CHRFAM7A;MAP2;YBX1;GATA2 |
MECP2 has several biochemical functions, for example, DNA binding, chromatin binding, double-stranded methylated DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MECP2 itself. We selected most functions MECP2 had, and list some proteins which have the same functions with MECP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NPAS2;SMAD9;GLI1;NFIL3;VDRB;PRRXL1;ZNF571;NABP2;HIST4H4 |
| chromatin binding | CBX1;PCNA;PAF1;TFAP2A;TWIST2;MSGN1;HIF1AB;STAT5B;TOX3 |
| double-stranded methylated DNA binding | MBD1;MECP2;H2AFY |
| histone deacetylase binding | SP1;BRMS1L;KAT2A;D7ERTD443E;NKX3;HDAC3;NKX3-1;HDAC4;BRMS1 |
| mRNA binding | DOM3Z;RBMY1A1;MRPS7;THOC2;KHSRP;SRRM4;XPO5;FXR1;ESRP1 |
| methyl-CpG binding | ZNF295;ZBTB4;MBD3L1;LRWD1;DNMT1;MBD3B;MECP2;MBD1B;MBD3A |
| poly(A) RNA binding | MRPL32;EIF3E;ETF1;HSPB1;HIST1H4H;NUCKS1;RBM22;MRM1;RPS14 |
| protein N-terminus binding | EXOC4;DAXX;FEZ1;RPA2;STX5;SLA2;LACRT;TAF11;MAP2K1 |
| protein binding | IQSEC3;FLII;MT1F;SPON2;LTC4S;IRF2BP1;SNX2;C19orf46;TUBA3E |
| protein domain specific binding | HIST1H4E;TNNI3;TWIST1;MPP5;EFS;YWHAG;NDE1;LIN7B;TJP2 |
| siRNA binding | MECP2;TLR9;DICER1;TARBP2;AGO2;TLR7 |
| transcription corepressor activity | AES;PBXIP1;NEUROD2;CRYM;RYBP;E2F7;PSMC3;RARA;HEYL |
| transcription factor activity, sequence-specific DNA binding | SUPT4H1;IKZF3;MEF2B;AFF4;VDRA;TRERF1;SCAND2P;BUD31;FOXP1B |
| transcription factor binding | GCM1;E2F2;PYDC3;HAND1;CTNNB1;NFATC2;HMGA1-RS1;TAF7L;MLXIPL |
MECP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MECP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MECP2.
Hipk2; SMARCA2; 64mer_ds_dna_probe; Atrx; HIPK2; SOX18; AIM2; H2AFY; PYHIN1
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