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MED27

Official Full Name

mediator complex subunit 27
Overview

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Synonyms

MED27; mediator complex subunit 27; cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa , CRSP8; mediator of RNA polymerase II transcription subunit 27; CRSP34; TRAP37; CRSP complex subunit 8; p37 TRAP/SMCC/PC2 subunit; transcriptional;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MED27-1909H	Recombinant Human MED27 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MED27-157H	Recombinant Human MED27, His-tagged	E.coli	His	1-311aa	Inquiry
Human	MED27-4385HCL	Recombinant Human MED27 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MED27-2109HF	Recombinant Full Length Human MED27 Protein, GST-tagged	In Vitro Cell Free System	GST	70 amino acids	Inquiry
Mouse	MED27-9699M	Recombinant Mouse MED27 Protein	Mammalian Cell	His		Inquiry
Mouse	MED27-5455M	Recombinant Mouse MED27 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MED27-5455M-B	Recombinant Mouse MED27 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	MED27-2723R	Recombinant Rhesus monkey MED27 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MED27-2543R	Recombinant Rhesus Macaque MED27 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MED27-2543R-B	Recombinant Rhesus Macaque MED27 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MED27-10929Z	Recombinant Zebrafish MED27	Mammalian Cell	His		Inquiry
Chicken	MED27-4755C	Recombinant Chicken MED27	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MED27 involved in several pathways and played different roles in them. We selected most pathways MED27 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone signaling pathway	MED12;EP300;MAP2K1;MED17;RXRG;PIK3R1;DIO1;ATP1B2;PIK3CA

MED27 has several biochemical functions, for example, protein binding, transcription coactivator activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED27 itself. We selected most functions MED27 had, and list some proteins which have the same functions with MED27. You can find most of the proteins on our site.

Function	Related Protein
protein binding	MED29;SH2D3A;ALDH3A1;ADORA1;HSP90B1;ARRB1;TNF;PCP4;TRIM22
transcription coactivator activity	HTATIP2;MKL1B;MED23;NFE2L3;SUB1B;TAF1;THRAP3;TFDP1;RNF4
ubiquitin protein ligase activity	HECTD3;UBE3B;RABGEF1;ASB4;FBXO30;FANCL;ANAPC11;MED17;DZIP3

MED27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED27 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED27.

MED10; MED19; MED22; Med30; CDK19; MED26; CDK8