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METAP2

  • Official Full Name

    methionyl aminopeptidase 2

  • Overview

    This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
  • Synonyms

    METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Spodoptera Frugiperda
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • HA
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human METAP2-203H Active Recombinant Human METAP2 protein, His-tagged Insect Cells His Met1-Tyr478
Human METAP2-630H Recombinant Human METAP2 protein, HA-tagged Insect Cell HA
Human METAP2-4415H Recombinant Human METAP2 Protein, GST-tagged Wheat Germ GST
Human METAP2-1109H Recombinant Human METAP2 Protein, His&SUMO-tagged E.coli N-His&SUMO Ala2-Tyr478
Human METAP2-1454H Recombinant Human METAP2 Protein (2-478 aa), His-tagged Yeast His 2-478 aa
Human METAP2-3948H Recombinant Human METAP2 Protein (Ala2-Tyr478), N-His tagged E.coli N-His Ala2-Tyr478
Human METAP2-6152HF Recombinant Full Length Human METAP2 Protein, GST-tagged In Vitro Cell Free System GST 478 amino acids
Human METAP2-2675H Recombinant Human METAP2 Protein (2-478 aa), His-Myc-tagged E.coli His/Myc 2-478 aa
Human METAP2-2780H Recombinant Human METAP2 protein(51-190 aa), C-His-tagged E. coli C-His 51-190 aa
Mouse METAP2-876M Active Recombinant Mouse METAP2 protein(Ala2-Tyr478), His-tagged Insect Cells C-His Ala2-Tyr478
Mouse METAP2-457MCL Recombinant Mouse METAP2 cell lysate Insect Cell N/A
Rat METAP2-3654R Recombinant Rat METAP2 Protein Mammalian Cell His
Rat METAP2-3310R Recombinant Rat METAP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat METAP2-3310R-B Recombinant Rat METAP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque METAP2-2736R Recombinant Rhesus monkey METAP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque METAP2-2557R Recombinant Rhesus Macaque METAP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque METAP2-2557R-B Recombinant Rhesus Macaque METAP2 Protein Pre-coupled Magnetic Beads HEK293
Chicken METAP2-1380C Recombinant Chicken METAP2 Mammalian Cell His
METAP2-635H Active Recombinant Human METAP2, His-tagged Spodoptera Frugiperda His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • METAP2 Related Research Area

METAP2 involved in several pathways and played different roles in them. We selected most pathways METAP2 participated on our site, such as Inactivation, recovery and regulation of the phototransduction cascade, Signal Transduction, The phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with METAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inactivation, recovery and regulation of the phototransduction cascadeMETAP2;GNB5A;CNGA1;METAP2A;METAP1;PPEF1;SAGB;RGS9BP;GRK7
Signal TransductionRYK;OXGR1A.2;IQCE;SKILB;LGR6;NPSR1;SOX13;FABP11A;OTULINB
The phototransduction cascadeNMT1B;CNGA1;METAP2;RLN1;GRK7;RGS9BP;METAP1;SAGB;NMT1A
Visual phototransductionCNGA1;CLPS;GUCA1E;DHRS9;BCO2;LRP12;RBP3;GRK7;RDH12

METAP2 has several biochemical functions, for example, aminopeptidase activity, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by METAP2 itself. We selected most functions METAP2 had, and list some proteins which have the same functions with METAP2. You can find most of the proteins on our site.

Function Related Protein
aminopeptidase activityXPNPEP1;METAP2;BLMH;TPP2;CTSL2;LTA4H;METAP2B;ANPEP;NPEPL1
hydrolase activitySACM1LB;Cel;SSH2B;NOTUM1A;C1rb;USP9;SETX;PM20D1.1;PLAUA
metal ion bindingCYP3A25;ZUFSP;ZNF561;ZNF547;TNKS2;AOC1;ENOPH1;FAM170A;ZNF192
metalloexopeptidase activityMETAP1D;NPEPL1;DPEP2;METAP2;DPEP3;LAP3;METAP2B;METAP1;METAP2A
peptidase activityBAP1;KEX2;Ctsl;FAM105B;HM13;CASPB;Gzmg;CAPN3A;CASP9
poly(A) RNA bindingMRPL1;ZFP36;SNRPA;ZNFX1;ATXN2L;SART1;DDX39B;TPT1;CPSF7
protein bindingMPPE1;KAT2A;FAM98A;SYCE1;INPP5D;DTNB;OCIAD1;DEPDC1;LSM2

METAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of METAP2.

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