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MFNG

Official Full Name

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Overview

This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.
Synonyms

MFNG; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; manic fringe (Drosophila) homolog , manic fringe homolog (Drosophila); beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; OTTHUMP00000197828;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Rat
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MFNG-4346HCL	Recombinant Human MFNG 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MFNG-1880H	Recombinant Human MFNG protein, His & T7-tagged	E.coli	His/T7	Ser80~Pro316 (Accession # O00587)	Inquiry
Human	MFNG-6198HF	Recombinant Full Length Human MFNG Protein, GST-tagged	In Vitro Cell Free System	GST	321 amino acids	Inquiry
Human	MFNG-4379H	Recombinant Human MFNG Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MFNG-4545H	Recombinant Human MFNG Protein (Ser80-Pro316), N-His tagged	E.coli	N-His	Ser80-Pro316	Inquiry
Mouse	MFNG-9786M	Recombinant Mouse MFNG Protein	Mammalian Cell	His		Inquiry
Mouse	MFNG-5517M-B	Recombinant Mouse MFNG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mfng-1881M	Recombinant Mouse Mfng protein, His & T7-tagged	E.coli	His/T7	Leu73~Pro310 (Accession # O09008)	Inquiry
Mouse	MFNG-5517M	Recombinant Mouse MFNG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Mfng-1882R	Recombinant Rat Mfng protein, His & T7-tagged	E.coli	His/T7	Ile56~Tyr309 (Accession # Q6P776)	Inquiry
Homo sapiens (Human)	RFL4411HF	Recombinant Full Length Human Beta-1,3-N-Acetylglucosaminyltransferase Manic Fringe(Mfng) Protein, His-Tagged	E.coli expression system	His	Full Length (1-321)	Inquiry
Mus musculus (Mouse)	RFL11940MF	Recombinant Full Length Mouse Beta-1,3-N-Acetylglucosaminyltransferase Manic Fringe(Mfng) Protein, His-Tagged	E.coli expression system	His	Full Length (1-321)	Inquiry
Zebrafish	MFNG-1862Z	Recombinant Zebrafish MFNG	Mammalian Cell	His		Inquiry

MFNG involved in several pathways and played different roles in them. We selected most pathways MFNG participated on our site, such as Other types of O-glycan biosynthesis, Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Other types of O-glycan biosynthesis	MGAT5B;B3GALTL;OGT;ST6GAL2A;FUT9A;RFNG;GLT25D2;ST3GAL3;FUT4
Notch signaling pathway	NOTCH4;NUMBL;APH1B;HER12;MAML2;HES1;DTX1;DVL1B;TUBB3

MFNG has several biochemical functions, for example, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFNG itself. We selected most functions MFNG had, and list some proteins which have the same functions with MFNG. You can find most of the proteins on our site.

Function	Related Protein
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	LFNG;RFNG;MFNG
metal ion binding	SMAP1;PPP1CA;CYP2X8;HBBE3;ICN2;CHEK2;S100A10A;ZNF518A;ACO1

MFNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFNG here. Most of them are supplied by our site. Hope this information will be useful for your research of MFNG.

Azam, SS; Akhunzada, MJ; et al. Structure and dynamic studies of lunatic, manic and radical fringe. JOURNAL OF MOLECULAR LIQUIDS 188:186-195(2013).

Gu, W; Xu, WG; et al. Fringe Controls Naive CD4(+)T Cells Differentiation through Modulating Notch Signaling in Asthmatic Rat Models. PLOS ONE 7:-(2012).

Notch Family