MITF
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Official Full Name
microphthalmia-associated transcription factor
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Overview
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
MITF; microphthalmia-associated transcription factor; MI; WS2; CMM8; WS2A; bHLHe32; class E basic helix-loop-helix protein 32;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Aspergillus fumigatus
- Chicken
- Human
- Mouse
- Neosartorya fumigata
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- GST|His
- His
- His (Fc)
- Avi
- SUMO
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MITF Related Articles
- MITF Related Research Area
MITF involved in several pathways and played different roles in them. We selected most pathways MITF participated on our site, such as Osteoclast differentiation, Melanogenesis, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MITF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | LILRB2;FYN;PIK3CD;TAB2;PIK3R1;FCGR3A;CYLD;CYBA;FOSL1 |
| Melanogenesis | GSK3B;PRKACAA;TCF7L2;CREB3L3;KITLGB;WNT11R;KITA;WNT7A;ASIP |
| Pathways in cancer | APC;ARNT;GNG3;CBL;DAPK3;RALGDS;MAP2K2;BDKRB1;WNT8A |
| Melanoma | AKT1;PDGFRB;FGF2;FGFR1;Pdgfa&Pdgfb;HRAS;IGF1R;BAD;KRAS |
MITF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MITF itself. We selected most functions MITF had, and list some proteins which have the same functions with MITF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFKB2;NFYC;EBF1;NFIB;MITFA;NFAT5;SMAD3;ZNF713;ESR1 |
| RNA polymerase II core promoter sequence-specific DNA binding | FOS;NSD1;SOX8;YAP1;H2AFZ;RBPJ;SMAD5;TRP53;HEYL |
| chromatin binding | ZEB1;GABPA;ATRX;KDM1A;UBE2T;POU2F1;LDB1;LRWD1;PHF21B |
| protein binding | ARFRP1;JRK;MAPK8IP2;PAEP;PPIL3;MICAL1;HBA1;PDE4D;EZR |
| protein dimerization activity | MXD1;TCF15;PIP;TFE3A;EBF3A;PRKRIR;TFE3;HEY2;BHLHA15 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | HNF1B;PDX1;SOX17;GLI1;SPI1;T;SRF;MYOD1;AHR |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TCF4;NR4A1;SMAD4;MYBL1;MYBL2;FOS;NFIC;POU3F2;SP1 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | BCL6;POU5F1;CGGBP1;MNT;ZNF350;ETV7;FERD3L;ARID5B;MSX1 |
MITF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MITF here. Most of them are supplied by our site. Hope this information will be useful for your research of MITF.
HK3; EBP; STUB1; YWHAZ
- Q&As
- Reviews
Q&As (5)
Ask a questionMITF is involved in the regulation of genes associated with invasion and metastasis in melanoma cells. Dysregulation of MITF can promote the metastatic potential of melanoma, making it an important factor to consider in clinical management.
While MITF itself may not be used as a standalone diagnostic marker, its expression levels, along with other molecular markers, can be integrated into diagnostic tools to provide a more comprehensive assessment of melanoma.
MITF has been associated with the downregulation of immune-related genes in melanoma cells, potentially contributing to resistance against immunotherapy. Understanding this interaction is crucial for developing strategies to overcome resistance.
MITF interacts with various signaling pathways, including the MAPK pathway. Understanding these interactions is crucial for unraveling the complex molecular networks involved in melanoma and for developing targeted therapeutic strategies.
MITF expression levels can be assessed through various laboratory techniques, including immunohistochemistry (IHC) on tissue samples. This provides valuable information for clinicians regarding the status of MITF in melanoma patients.
Customer Reviews (3)
Write a reviewThey consistently stay at the forefront of scientific advancements and customer feedback, allowing them to refine the MITF protein based on emerging research trends.
This high-quality protein serves as an invaluable tool in unraveling the intricate mechanisms governed by MITF, enabling me to gain deeper insights into its functions and implications.
An outstanding aspect of the manufacturer of the MITF protein is their commitment to providing excellent technical support.
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