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MKL1

Official Full Name

megakaryoblastic leukemia (translocation) 1
Overview

MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
Synonyms

MKL1; megakaryoblastic leukemia (translocation) 1; MKL/myocardin-like protein 1; basic; SAP and coiled coil domain; BSAC; KIAA1438; MAL; megakaryocytic acute leukemia; MRTF A; myocardin related transcription factor A; basic, SAP and coiled-coil domain; me;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MKL1-893H	Recombinant Human MKL1, GST-tagged	E.coli	GST	392-741aa	$319 / 25ug
Human	MKL1-1153H	Recombinant Human MKL1 protein, His-KSI-tagged	E.coli	His-KSI	400-500aa	Inquiry
Mouse	MKL1-9861M	Recombinant Mouse MKL1 Protein	Mammalian Cell	His		Inquiry
Mouse	MKL1-5572M-B	Recombinant Mouse MKL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MKL1-5572M	Recombinant Mouse MKL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MKL1 involved in several pathways and played different roles in them. We selected most pathways MKL1 participated on our site, such as RHO GTPase Effectors, RHO GTPases Activate Formins, RhoA signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RHO GTPase Effectors	CIT;RANGAP1B;NOXO1A;EVL;DSN1;NCKAP1;NDEL1B;NF2A;ABI2
RHO GTPases Activate Formins	CLIP1;SKA2;AHCTF1;FMNL2;SPC25;MKL1B;NDEL1A;RHOAE;DSN1
RhoA signaling pathway	MKL1;DIAPH1;ACTA1;CYR61
Signal Transduction	OPN5;WIPF3;ROR1;DHRS3;RGS10;QRFP;SHB;FGFBP1;GRK7
Signaling by Rho GTPases	ARHGAP40;DEPDC1B;FAM13B;RHOJ;CHN2;ARHGAP25;ARHGAP29;DLC1;MYO9B

MKL1 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, actin binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKL1 itself. We selected most functions MKL1 had, and list some proteins which have the same functions with MKL1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription coactivator activity	PRRX1;CITED1;NEUROD1;CREBBP;RERE;MYOCD;HYAL2;MKL1B;POU3F1
actin binding	MTAP1B;EPS8;MARCKSL1;CAPGA;PARVG;DBNL;Fert2;CCDC88A;PARK2
actin monomer binding	KLHL8;ABL1;COBLL1;ABL2;TMSB4X;MKL1B;PFN1;TMSB;PKNOX2
leucine zipper domain binding	PMF1;DAPK3;KCNA3;ATF4;ERC1;PAWR;NRL;AATF;CRX
protein binding	RBP5;PDCD6IP;PIDD1;RECQL4;CRCT1;GP9;DEFB121;ZFC3H1;UBOX5
transcription coactivator activity	E4F1;MED23;PQBP1;PARK7;GTF2A1;MYOD1;NFATC4;NR2F1;MED27
transcription factor activity, sequence-specific DNA binding	ARNTL1A;CSRNP1;HES1;FOXF2A;HOXA3A;MYBL2;HOXD4A;ZNF621;REL
transcription regulatory region sequence-specific DNA binding	FOXN1;NFE2L3;PITX2;NONO;NFKB1;NFE2;MKL1;PSPC1;NFE2L2A

MKL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKL1.

SRF; MKL2; frwC; MYC