MKNK2
-
Official Full Name
MAP kinase interacting serine/threonine kinase 2
-
Overview
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. -
Synonyms
MKNK2; MAP kinase interacting serine/threonine kinase 2; G protein coupled receptor kinase 7 , GPRK7; MAP kinase-interacting serine/threonine-protein kinase 2; MNK2; Putative map kinase interacting kinase; MAP kinase signal integrating kinase 2; G protein coupled receptor kinase 7; GPRK7; MAP kinase interacting serine threonine kinase 2; MAP kinase interacting serine threonine kinase; MAP kinase interacting serine threonine protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK interacting kinase 2; Mitogen activated protein kinase interacting serine threonine kinase 2; MKNK2_HUMAN; G protein-coupled receptor kinase 7;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MKNK2 Related Articles
MKNK2 involved in several pathways and played different roles in them. We selected most pathways MKNK2 participated on our site, such as MAPK signaling pathway, HIF- signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | STMN1B;HSP70L;FGFR1A;ZAK;MAPK4;FGF16;MAPK8;PAK1;RPS6KA3B |
| HIF- signaling pathway | HK3;TFRC;PFKL;INS2;PFKFB3;LDHA;PIK3R1;ANGPT1;AKT1 |
| Insulin signaling pathway | CALM1A;PRKAG3;MKNK2;SOCS3B;INSR;PPP1CA;FLOT2;IRS4;PPP1R3A |
MKNK2 has several biochemical functions, for example, ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKNK2 itself. We selected most functions MKNK2 had, and list some proteins which have the same functions with MKNK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMK1GA;INSRA;BCKDK;CCT3;SLC27A2;FUK;NEK4;CKMT2B;POMK |
| calcium-dependent protein serine/threonine kinase activity | CAMK1GB;MKNK2;CAMK4;MAPKAPK2;MKNK2B;MAPKAPK2B;MKNK2A;MKNK1;MAPKAPK2A |
| calmodulin binding | KCNN1;KCNN1B;NOS3;MKNK2B;STRN4;TRPM4;PPP3CA;RIT1;KCNN4 |
| calmodulin-dependent protein kinase activity | DAPK1;MYLK3;ITPKA;MAPKAPK2;CAMKK1;CAMK2B1;MAPKAPK2A;MYLK2;MAPKAPK2B |
| metal ion binding | ZFP932;ZNF596;ADH8A;RNASEL;TRIM43A;LMTK3;FAM96A;Adamts19;BCL11A |
| protein binding | TSPAN12;BIN1;PLD1;ZFP64;CHEK2;BTG3;CDKN1A;APOOL;UCN |
| protein serine/threonine kinase activity | STK3;MAPK12B;CIT;MAP3K11;PAK7;NIM1;STK40;MARK1;BUB1B |
MKNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKNK2.
MAPK14; LRRK2; SRPK1; MAPK8; RPL7A; syd; WWP2; WDR46; NUDT21; EXOC3; MIF; VCL; CSTF2; BAG6; PLXNA3; TRAP1; NOLC1
- Q&As
- Reviews
Ask a Question for All MKNK2 Products
Required fields are marked with *
My Review for All MKNK2 Products
Required fields are marked with *
