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MLLT4

Official Full Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Overview

This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
Synonyms

MLLT4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); afadin; AF 6; AF6; protein AF-6; ALL1-fused gene from c;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
E.Coli or Yeast
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MLLT4-29200TH	Recombinant Human MLLT4, GST-tagged	E.coli	GST		Inquiry
Human	MLLT4-1011H	Recombinant Human MLLT4, Ras-binding Domain	E.coli	N/A		Inquiry
Mouse	MLLT4-9888M	Recombinant Mouse MLLT4 Protein	Mammalian Cell	His		Inquiry
Mouse	MLLT4-5587M	Recombinant Mouse MLLT4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MLLT4-5587M-B	Recombinant Mouse MLLT4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MLLT4-3703R	Recombinant Rat MLLT4 Protein	Mammalian Cell	His		Inquiry
Rat	Mllt4-3234R	Recombinant Rat Mllt4, His-tagged	E.Coli or Yeast	His	1829	Inquiry
Rat	MLLT4-3359R-B	Recombinant Rat MLLT4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MLLT4-3359R	Recombinant Rat MLLT4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MLLT4 Related Articles

MLLT4 involved in several pathways and played different roles in them. We selected most pathways MLLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	RAC3;PDGFRA;KRAS;PAK1;RALBP1;PDGFRB;FGF20;IKBKG;ETS2
Rap signaling pathway	PRKCB;FGFR2;Fgf15;GNAO1;MAPK11;F2RL3;PRKCZ;PLCB3;LPAR2
cAMP signaling pathway	GRIN3A;ROCK1;PPP1CA;LOC100328615;NFATC1;NFKBIA;HTR1A;MAPK10;GRIA3
Adherens junction	WASF2;FGFR1;TCF7L2;MAPK1;BAIAP2A;CTNNA2;CDC42L;MAP3K7;FARP2
Tight junction	CLDN5;RHOAC;CLDN7A;MYL2B;RHOAA;EPB41L3;HRASB;MYL5;PPP2R2CA
Leukocyte transendothelial migration	NCF1;ROCK1;MMP2;ACTN2;BCAR1;JAM2;CLDN8;VAV2;PTPN11

MLLT4 has several biochemical functions, for example, Ras GTPase binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLLT4 itself. We selected most functions MLLT4 had, and list some proteins which have the same functions with MLLT4. You can find most of the proteins on our site.

Function	Related Protein
Ras GTPase binding	SPHK2;RASGRP3;PLCE1;RGL3;RAPGEF6;RAPGEF4;RAP1GAP;RIN1;MAPKAP1
protein C-terminus binding	YAP1;ATXN2;ITGB3BP;RBFOX1;VPS4A;ABL1;SP1;NPAT;LCK
protein binding	MAP3K7IP3;GABARAPL1;RPS16;WWOX;KLK8;KRT6B;C22orf13;TNK1;THAP7

MLLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLLT4.

SRC; PVRL3; YWHAG; PVRL2; LMO2; DBN1

Aalbers, AM; van den Heuvel-Eibrink, MM; et al. Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood. HAEMATOLOGICA 100:315-323(2015).

Baird, JH; Minniti, CP; et al. Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide. BRITISH JOURNAL OF HAEMATOLOGY 168:737-746(2015).