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MMP1

  • Official Full Name

    matrix metallopeptidase 1 (interstitial collagenase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms

    MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Pig
  • Rabbit
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Fibroblasts
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • MBP
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP1-126H Active Recombinant Human MMP1 Protein, His-tagged HEK293 His Phe20-Asn469
Human MMP1-1713H Active Recombinant Human MMP1 E.coli N/A
Human MMP1-149H Recombinant Human Matrix Metallopeptidase 1, Hemopexin-like Domain E.coli N/A
Human MMP1-407H Recombinant Human Matrix Metallopeptidase 1 Mammalian cells N/A
Human MMP1-566H Recombinant Human MMP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MMP1-91H Recombinant Human MMP1 protein, T7/His-tagged E.coli T7/His
Human MMP1-568H Recombinant Human MMP1 Protein, His-tagged E.coli His
Human MMP1-809H Recombinant Human MMP1 protein, His-tagged HEK293 His Phe20-Asn469
Human MMP1-445H Recombinant Human matrix metallopeptidase 1 (interstitial collagenase), His-tagged E.coli His
Human MMP1-26H Recombinant Human MMP1 protein, His-tagged Insect Cell His
Human MMP1-2884HCL Recombinant Human MMP1 cell lysate Human Cell N/A
Human MMP1-2983H Recombinant Human MMP1 protein, His-tagged E.coli His 428-469 aa
Human MMP1-45H Native Human MMP-1 Human Fibroblasts N/A
Human MMP1-148H Recombinant Human Matrix Metallopeptidase 1, Catalytic Domain E.coli N/A
Human MMP1-5412H Active Recombinant Human MMP1 Protein E.coli N/A
Human MMP1-799H Recombinant Human MMP1 Protein, His-tagged HEK293 His
Human MMP1-5413H Recombinant Human MMP1 Protein, GST-tagged Wheat Germ GST
Human MMP1-6400HF Recombinant Full Length Human MMP1 Protein, GST-tagged In Vitro Cell Free System GST 469 amino acids
Human MMP1-4560H Active Recombinant Human MMP1 protein(Met1-Asn469), His-tagged HEK293 C-His Met1-Asn469
Human MMP1-4450H-B Recombinant Human MMP1 Protein Pre-coupled Magnetic Beads HEK293
Human MMP1-4231H Recombinant Human MMP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MMP1-238H Recombinant Active Human MMP1 Protein, His-tagged(C-ter) HEK293 His(C-ter) Phe20-Asn469
Human MMP1-4561H Recombinant Human MMP1 Protein (Phe20-Asn469), N-His tagged E.coli N-His Phe20-Asn469
Human MMP1-4450H Recombinant Human MMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP1-1114H Recombinant Human MMP1 Protein, His-tagged CHO N-His Phe20-Asn469
Human MMP1-2535H Recombinant Human MMP1 protein(111-290 aa), N-MBP & C-His-tagged E. coli N-MBP & C-His 111-290 aa
Human MMP1-2536H Recombinant Human MMP1 protein(20-469 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 20-469 aa
Rat Mmp1-726R Recombinant Rat Mmp1 protein, His & T7-tagged E.coli His/T7 Asn169~Cys464 (Accession# B5DFD5)
Rabbit MMP1-1115R Recombinant Rabbit MMP1 Protein, His-tagged E.coli N-His Phe99-Pro268
Cattle MMP1-724C Recombinant Cattle MMP1 protein, His & T7-tagged E.coli His/T7 Phe19~Asn469 (Accession# P28053)
Pig MMP1-1116P Recombinant Pig MMP1 Protein, His-tagged E.coli N-His Phe100-Asn469
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MMP1 Related Articles
  • MMP1 Related Gene Family
  • MMP1 Related Research Area

MMP1 involved in several pathways and played different roles in them. We selected most pathways MMP1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayPCK2;ACAA1;HMGCS2;UBC;FABP3;AQP7;CYP4A12A;Scd2;APOA1A
Pathways in cancerWNT8B;PLCB1;RALGDS;FZD6;FZD9;ETS1;FIGF;WNT8A;STAT1
Bladder cancerMYC;UPK3A;NRAS;DAPK2;RB1;MDM2;IL-8;ARAF;CCND1
Rheumatoid arthritisITGAL;CCL5;IL6;HLA-DQB1;Il23a;HLA-DPA1;ATP6V0E;TNFRSF11A;IL23

MMP1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP1 itself. We selected most functions MMP1 had, and list some proteins which have the same functions with MMP1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDH2AB2;PCDHB2;MYL2B;PADI6;PCDH1G18;AP1S2;SCUBE3;SCUBE2;SULF2A
endopeptidase activityACE;KLK1B11;PSMA6A;CPS1;SENP3A;PSMB2;HTRA4;KLK1B22;KLK1B16
metalloendopeptidase activitySPG7;ADAM7;ADAMTS20;ADAM33;ADAMTS16;UQCRC2;Adam6;ADAM28;IDE
zinc ion bindingZDHHC1;LHX1B;PCGF2;PHC2B;LTA4H;ING4;CNBP;MKRN2;ESRRGB

MMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP1.

F2R; SOX8

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Kumar, D; Moore, RM; et al. Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening. PLACENTA 35:1049-1056(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does MMP1 relate to wound healing? 02/09/2023

MMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.

Are there therapeutic implications of targeting MMP1 in cancer treatment? 11/11/2022

Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.

How does MMP1 contribute to tissue remodeling? 05/07/2020

MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.

In what diseases is MMP1 overexpressed? 08/21/2017

MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.

Can MMP1 be a biomarker for prognosis in cancer patients? 02/18/2017

High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.

Customer Reviews (3)

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Reviews
08/26/2021

    The manufacturer can offer technical support and expertise to guide researchers through the experimental process.

    11/09/2020

      The manufacturer can play a vital role in supporting and optimizing the research process.

      07/20/2020

        This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.

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