mmp12
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  • Official Full Name
  • matrix metallopeptidase 12 (macrophage elastase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP12; matrix metallopeptidase 12 (macrophage elastase); ME; HME; MME; MMP-12; macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase)
Cat.#:MMP12-1283HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12 Protein, His-tagged
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Cat.#:MMP12-164HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12(Macrophage Elastase), Inactive, Catalytic Domain
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Cat.#:MMP12-06HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12 protein, His-tagged
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Cat.#:MMP12-1133HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP12, His tagged
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Cat.#:MMP12-157HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12
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Cat.#:MMP12-158HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12
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Cat.#:MMP12-28717THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12, His-tagged
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Cat.#:Mmp12-533MTag:His
Source (Host):Human CellsSpecies:Mouse
Product nameRecombinant Mouse Mmp12 protein, His-tagged
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Cat.#:Mmp12-534MTag:
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Mmp12
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Cat.#:Mmp12-600MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp12 Protein, His-tagged
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Cat.#:MMP12-9907MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP12 Protein
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Cat.#:MMP12-3712RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP12 Protein
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Cat.#:Mmp12-602RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-603RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-604RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-605RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:MMP12-606RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit MMP12 Protein, His-tagged
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Cat.#:MMP12-4281HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP12 293 Cell Lysate
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Cat.#:CSC-P0953Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0954Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0955Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 scFv Stable Cell Line-CHO
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MMP12 Related Articles

Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
John-Schuster, G; Hager, K; et al. Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307:L692-L706(2014).

MMP12 Related Gene Family

MMPs