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MMP3

  • Official Full Name

    matrix metallopeptidase 3 (stromelysin 1, progelatinase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Assay Kits
  • Cattle
  • Clostridium histolyticum
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP3-224H Active Recombinant Human MMP3 Protein E.coli N/A
Human MMP3-200H Active Recombinant Human MMP3, His-tagged HEK293 His
Human MMP3-197H Active Recombinant Human MMP3 protein E.coli N/A Tyr18-Thr272
Human MMP3-049H Recombinant Human Matrix Metallopeptidase 3 (stromelysin 1, progelatinase) E.coli N/A
Human MMP3-1383H Recombinant Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase), GST-Tagged Human GST
Human MMP3-5080H Recombinant Human MMP3, His-tagged E.coli His
Human MMP3-740H Recombinant Human MMP3 Protein, His-tagged HEK293 His
Human MMP3-163H Recombinant Human MMP3 (Stromelysin 1, Progelatinase), Inactive, Catalytic Domain E.coli N/A
Human MMP3-479H Recombinant Human matrix metallopeptidase 3 (stromelysin 1, progelatinase), His-tagged E.coli His
Human MMP3-28202TH Recombinant Human MMP3, His-tagged His
Human MMP3-39H Recombinant Human MMP3 E.coli N/A
Human MMP3-555H Recombinant Human MMP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MMP3-152H Recombinant Human Matrix Metallopeptidase 3, Catalytic Domain E.coli N/A
Human MMP3-4273HCL Recombinant Human MMP3 293 Cell Lysate HEK293 N/A
Human MMP3-5433H Recombinant Human MMP3 Protein, GST-tagged Wheat Germ GST
Human MMP3-1420H-B Recombinant Human MMP3 Protein Pre-coupled Magnetic Beads HEK293
Human MMP3-780H Recombinant Human MMP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MMP3-2450H Recombinant Human MMP3 Protein, His-tagged E.coli N-His Arg101-Cys477
Human MMP3-3235H Recombinant Human MMP3 protein, His-SUMO-tagged E.coli His-SUMO 102-477aa
Human MMP3-890HFL Recombinant Full Length Human MMP3 Protein, C-Flag-tagged Mammalian cells Flag
Human MMP3-1123H Recombinant Human MMP3 Protein, His-tagged HEK293F N-His Tyr18-Cys477
Human MMP3-0392H Active Recombinant Human MMP3 protein, His-tagged HEK293 His Tyr18-Thr272
Human MMP3-1420H Recombinant Human MMP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP3-2449H Recombinant Human MMP3 Protein, His-tagged E.coli N-His Tyr18-Cys477
Human MMP3-1238H Active Recombinant Human MMP3 protein, His-tagged HEK293 His Tyr18-Cys477
Human MMP3-6279HF Recombinant Full Length Human MMP3 Protein, GST-tagged In Vitro Cell Free System GST 477 amino acids
Human MMP3-1239H Active Recombinant Human MMP3 protein, His-tagged HEK293 His Tyr18-Cys477
Human MMP3-240H Recombinant Human MMP3 Protein, His-tagged(C-ter) HEK293 His(C-ter) Tyr18-Cys477
Human MMP3-0029H Recombinant Human MMP3 Protein HEK293 cells
Mouse Mmp3-416M Active Recombinant Mouse Mmp3 protein Mammalian cells N/A
Mouse MMP3-9924M Recombinant Mouse MMP3 Protein Mammalian Cell His
Mouse Mmp3-743M Recombinant Mouse Mmp3 protein, His & T7-tagged E.coli His/T7 Phe100~Cys477 (Accession # P28862)
Mouse Mmp3-10594M-B Recombinant Mouse Mmp3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mmp3-10594M Recombinant Mouse Mmp3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mmp3-5318M Recombinant Mouse Mmp3 protein, His-tagged E.coli His 104-477aa
Rat Mmp3-745R Recombinant Rat Mmp3 protein, His-tagged E.coli His Asn278~Gly450
Rabbit MMP3-1124R Recombinant Rabbit MMP3 Protein, His-tagged E.coli N-His Phe101-Cys478
Cattle MMP3-739C Recombinant Cattle MMP3 protein, His & T7-tagged E.coli His/T7 Tyr18~Cys477
Clostridium histolyticum MMP3-26C Collagenase Type 3 Protein N/A
Pig MMP3-744P Recombinant Pig MMP3 protein, His & T7-tagged E.coli His/T7 Tyr18~Cys477 (Accession# F1SV58)
Pig MMP3-1117P Recombinant Pig MMP3 Protein, His-tagged E.coli N-His Tyr18-Cys477
Kit-0589 MMP-3 Activity Assay Kit N/A
Kit-2213 MMP-3 Activity Fluorometric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MMP3 Related Gene Family

MMP3 involved in several pathways and played different roles in them. We selected most pathways MMP3 participated on our site, such as TNF signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TNF signaling pathwayMAPK1;BIRC2;LIF;CREB5;MAP3K7;MAP2K1;CCL20;NFKBIA;MAPK9
Transcriptional misregulation in cancerHDAC1;PAX5;MAX;IL1R2;ITGB7;CCNT2;CEBPE;MYCN;SLC45A3
Rheumatoid arthritisTLR4;TNFSF13;IL11;MMP3;ATP6V0E;CCL3L3;TLR2;FOS;ATP6V1G2

MMP3 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP3 itself. We selected most functions MMP3 had, and list some proteins which have the same functions with MMP3. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDH1G18;PSPH;SYTL4;PCDH2AA15;S100G;GSNA;C1S;SLC24A4A;ANXA3
endopeptidase activityTRAPPC12;MMP1A;PSMA5;PSMB1;NAPSA;PSMB9A;KLK1B22;PSMA2;ECE1
metalloendopeptidase activityMMP14;BMP1A;ADAM8;FAP;ADAM10;MME;PMPCB;THSD4;MEP1B
protein bindingCEP72;HIST1H4L;AURKAIP1;AHCYL2;FGFR2;TCEAL5;ANG;SART3;HAAO
zinc ion bindingPDLIM3B;TRIM62;TRIM40;PDLIM7;S100A5;RNF148;ADH7;PHC2A;MKRN3

MMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP3.

MEOX2; TIMP1

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

Customer Reviews (3)

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Reviews
12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

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