MRPL22
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Official Full Name
mitochondrial ribosomal protein L22
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Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MRPL22; mitochondrial ribosomal protein L22; 39S ribosomal protein L22, mitochondrial; HSPC158; MRP L25; RPML25; 39S ribosomal protein L22 mitochondrial precursor; L22mt; MRP L22; L25mt; 39S ribosomal protein L25, mitochondrial; MRP-L22; MRP-L25;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MRPL22 involved in several pathways and played different roles in them. We selected most pathways MRPL22 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPS11;RPL9;MRPL35;RPS19;RPS16;RPS17L;RPL21;MRPL2;RSL24D1 |
MRPL22 has several biochemical functions, for example, poly(A) RNA binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL22 itself. We selected most functions MRPL22 had, and list some proteins which have the same functions with MRPL22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | AKAP8;TNRC6B;BRIX1;HIST1H1D;DHX33;EIF2S1B;RPL23A;CSTF2;HNRNPU |
| structural constituent of ribosome | RPL10;RPS6;RPL7A;MRPL12;RPL11;RPS26;MRPL32;MRPS30;RPS24 |
MRPL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL22.
C1qbp; Ppp2ca; ICT1; MRPL50; MRPL9
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