MRPL49
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Official Full Name
mitochondrial ribosomal protein L49
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Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. -
Synonyms
MRPL49; mitochondrial ribosomal protein L49; C11orf4, chromosome 11 open reading frame 4; 39S ribosomal protein L49, mitochondrial; L49mt; neighbor of FAU; next to FAU; NOF; NOF1; 39S ribosomal protein L49 mitochondrial; C11orf4; Chromosome 11 open reading frame 4; MGC10656; MRP L49; Protein NOF1; RM49; MRP-L49;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MRPL49 involved in several pathways and played different roles in them. We selected most pathways MRPL49 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL49 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation | MRPL47;GADD45GIP1;MRPS30;MRPS36;MRPS34;MRPL52;MRPL55;TUFM;MRPS25 |
| Mitochondrial translation elongation | MRPS23;TSFM;MRPS28;MRPL50;MRPL47;MRPL53;MRPS30;MRPL52;MRPS24 |
| Mitochondrial translation initiation | MRPL37;MRPL3;MRPS27;MRPL47;MRPL39;MRPL28;MRPL46;MRPS22;MTFMT |
| Mitochondrial translation termination | AURKAIP1;MRPL46;MRPL53;DAP3;MRPS25;MRPS27;MTRF1L;MRPL44;MRPL47 |
| Organelle biogenesis and maintenance | MRPL44;MRPS22;MARK4;PTCD3;TCTN1;MRPS24;IFT22;GADD45GIP1;IFT74 |
MRPL49 has several biochemical functions, for example, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL49 itself. We selected most functions MRPL49 had, and list some proteins which have the same functions with MRPL49. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PADI4;MAPRE1;NOMO2;CIB1;CTDNEP1;PBX2;FLOT1;ZFP161;MRPS27 |
| structural constituent of ribosome | FAUB;MRPS18C;RPS17;SLC25A47A;RPSA;MRPL16;MRPS16;MRPL21;DAP3 |
MRPL49 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL49 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL49.
Brwd3; YBX1; ICT1; Fbxw11; Osgep; Spire2; MRPL50; MRPL9; MRPL1; Ecd
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