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MRPS22

Official Full Name

mitochondrial ribosomal protein S22
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.
Synonyms

MRPS22; mitochondrial ribosomal protein S22; 28S ribosomal protein S22, mitochondrial; C3orf5; GIBT; GK002; MRP S22; COXPD5; RPM S22; RPMS22; S22mt; MRP-S22;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPS22-4144HCL	Recombinant Human MRPS22 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MRPS22-6484HF	Recombinant Full Length Human MRPS22 Protein, GST-tagged	In Vitro Cell Free System	GST	360 amino acids	Inquiry
Human	MRPS22-5610H	Recombinant Human MRPS22 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRPS22-2148H	Recombinant Human MRPS22 Protein (1-360 aa), GST-tagged	E.coli	GST	1-360 aa	Inquiry
Mouse	MRPS22-10094M	Recombinant Mouse MRPS22 Protein	Mammalian Cell	His		Inquiry
Mouse	MRPS22-5719M	Recombinant Mouse MRPS22 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Mrps22-4169M	Recombinant Mouse Mrps22 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	MRPS22-5719M-B	Recombinant Mouse MRPS22 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MRPS22-5699Z	Recombinant Zebrafish MRPS22	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRPS22 Related Articles

MRPS22 involved in several pathways and played different roles in them. We selected most pathways MRPS22 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPS22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mitochondrial translation	MRPL47;MTFMT;MRPS22;DAP3;MRPL41;GADD45GIP1;MTIF3;MRPL46;MRRF
Mitochondrial translation elongation	MRPS23;MRPL55;MRPL3;MRPS34;MRPL39;MRPL46;AURKAIP1;MRPS26;TUFM
Mitochondrial translation initiation	MRPS23;MRPS26;MRPL39;MRPL37;MRPL38;MTFMT;MRPL50;CHCHD1;MRPL42
Mitochondrial translation termination	ICT1;MRPL54;MRPS25;MRPS35;MRPL50;MRPS31;MRPL41;MRPS22;MTRF1L
Organelle biogenesis and maintenance	TTC30A1;MRPL38;WDR35;TTBK2;IFT52;IFT43;PKD1;TNPO1;MRPL55

MRPS22 has several biochemical functions, for example, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPS22 itself. We selected most functions MRPS22 had, and list some proteins which have the same functions with MRPS22. You can find most of the proteins on our site.

Function	Related Protein
structural constituent of ribosome	MRPS2;MRPL22;RPL23A;MRPL14;MRPS30;RPL35;MRPS31;MRPL35;RPSA

MRPS22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPS22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPS22.

C1qbp; ESR2; Ybx1; NFKBIL1; BTK; SHD; Smad6; MYC; ESR1; TP53; ERBB3; YBX1; ICT1; MAP1LC3A; AGO2; AGO1; SIRT4

Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).