MS4A1
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Official Full Name
membrane-spanning 4-domains, subfamily A, member 1
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Overview
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cynomolgus
- Cynomolgus Monkey
- Dog
- Ferret
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Mus musculus (Mouse)
- Baculovirus-Insect cells
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Biotin|Fc
- Fc
- Flag
- Flag,8His
- GFP
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- His|trxA
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- 8×His
- TEV
- Trx
- TrxA
- Involved Pathway
- Protein Function
- Interacting Protein
- MS4A1 Related Articles
- MS4A1 Related Research Area
MS4A1 involved in several pathways and played different roles in them. We selected most pathways MS4A1 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with MS4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hematopoietic cell lineage | FLT3LG;Kitl;CD4;IL9R;HLA-DRB5;KIT;DNTT;IL5;CD24 |
MS4A1 has several biochemical functions, for example, MHC class II protein complex binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MS4A1 itself. We selected most functions MS4A1 had, and list some proteins which have the same functions with MS4A1. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class II protein complex binding | CD81;HLA-DMA;YWHAE;MS4A1;HLA-DOA;PKM2;HSP90AA1;HLA-DRB1;HLA-DOB |
epidermal growth factor receptor binding | BTC;HBEGFB;SNX2;SNX1;ARF4;MS4A1;LINGO1;EFEMP1;EREG |
protein binding | WBSCR27;MBP;SPON1;RAB18;ARNT;SLC6A20B;CBFA2T3;BCLAF1;CIRH1A |
MS4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MS4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MS4A1.
CCDC155; IGHM; IGHD; CREB3; xthA; tyrS
- Q&As
- Reviews
Q&As (7)
Ask a questionMS4A1 expression is tightly regulated during different stages of B-cell development. It is absent in early B-cell progenitors and gradually increases during maturation. MS4A1 expression is upregulated upon B-cell activation and can be influenced by various cytokines and signaling pathways. This tightly controlled expression pattern ensures proper B-cell development, while aberrant regulation may contribute to B-cell disorders or malignancies.
MS4A1 expression levels have been explored as potential diagnostic or prognostic markers for certain B-cell disorders. Quantification of CD20 expression by immunohistochemistry or flow cytometry can aid in the diagnosis and classification of B-cell malignancies. Additionally, low CD20 expression levels have been associated with resistance to CD20-targeted therapies, serving as a prognostic indicator in B-cell lymphomas.
While CD20-targeted antibodies have revolutionized the treatment of B-cell malignancies, further therapeutic strategies are being explored. These include enhancing CD20 internalization, using antibody-drug conjugates, and developing novel targeted therapies based on the signaling pathways associated with MS4A1. Investigating these approaches may provide alternative treatments and improve outcomes for patients with B-cell disorders.
MS4A1 helps maintain immune tolerance by preventing the production of autoreactive B cells. It contributes to the elimination of self-reactive B cell clones through mechanisms such as antibody-dependent cellular cytotoxicity and antibody-mediated phagocytosis. MS4A1 dysregulation, however, can lead to the production of autoantibodies and the development of autoimmune diseases. Understanding the fine-tuned regulation of MS4A1's functions is essential for maintaining immune homeostasis and preventing autoimmunity.
MS4A1 interacts with multiple proteins, such as tetraspanins, Src-family kinases, and lipid rafts, which form a complex network involved in B-cell signaling. Upon ligand binding, MS4A1 activates intracellular signaling pathways, including PI3K/Akt and MAPK/ERK, which regulate B-cell survival, proliferation, and differentiation. Understanding these pathways and their crosstalk with MS4A1 can provide insights into B-cell activation and potential therapeutic targets.
The MS4A1 protein, also known as CD20, is a tetraspanin membrane protein found predominantly in B cells. It plays a crucial role in B-cell development, activation, and antibody production. Structurally, CD20 consists of four transmembrane domains and a large extracellular loop. Functionally, it regulates B-cell signaling by promoting calcium influx upon B-cell receptor activation, modulating cell cycle progression, and facilitating antibody-mediated cytotoxicity.
MS4A1 dysregulation has been implicated in B-cell malignancies, including non-Hodgkin lymphomas and leukemia. Increased expression or altered signaling of MS4A1 may promote survival and proliferation of malignant B cells. CD20-targeted therapies, such as monoclonal antibodies, have been successfully employed in treating B-cell malignancies, highlighting the significance of MS4A1 as a therapeutic target in these diseases.
Customer Reviews (3)
Write a reviewIts strong affinity allows for robust binding to target proteins, thereby enhancing the accuracy of analysis.
Surpassing expectations, it significantly amplifies the results of my research.
The operational guidelines for this reagent are readily comprehensible and accessible, facilitating seamless implementation of experiments, even for individuals lacking prior expertise.
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